Warm autoadsorption using ZZAP

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 34 , ISSUE 1 (March 2018) > List of articles

Warm autoadsorption using ZZAP

Farai M. Tsimba-Chitsva * / Amy Caballero / Becky Svatora

Keywords : warm autoadsorption, warm autoantibodies, ZZAP-treated RBCs, autoimmune hemolytic anemia

Citation Information : Immunohematology. Volume 34, Issue 1, Pages 1-3, DOI: https://doi.org/10.21307/immunohematology-2018-001

License : (Transfer of Copyright)

Published Online: 16-October-2019

ARTICLE

ABSTRACT

The masking of clinically significant alloantibodies by warm autoantibodies presents challenges in pretransfusion testing. The adoption of transfusion practices such as the issuing of “least incompatible” red blood cells (RBCs) without a complete antibody workup is potentially unsafe for patients. Several autoadsorption methods can be used to remove autoantibody reactivity. ZZAP treatment of autologous RBCs is an efficient way to prepare the cells for autoadsorption. Autoadsorbed serum or plasma can then be used to remove autoantibody reactivity and identify clinically significant alloantibodies.

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