Clinical significance of antibodies to antigens in the International Society of Blood Transfusion collections, 700 series of low-incidence antigens, and 901 series of high-incidence antigens

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 34 , ISSUE 2 (June 2018) > List of articles

Clinical significance of antibodies to antigens in the International Society of Blood Transfusion collections, 700 series of low-incidence antigens, and 901 series of high-incidence antigens

Christine Lomas-Francis *

Keywords : clinical significance, antibodies to red blood cell (RBC) antigens, International Society of Blood Transfusion (ISBT) collections, low-incidence antigens, high-incidence antigens

Citation Information : Immunohematology. Volume 34, Issue 2, Pages 39-45, DOI: https://doi.org/10.21307/immunohematology-2018-007

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Published Online: 16-October-2019

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ABSTRACT

This article reviews information regarding the clinical significance of antibodies to antigens in the blood group collections, the 700 series of low-incidence antigens, and the 901 series of high-incidence antigens. Antibodies to many of the antigens in these groups are rarely encountered, meaning that available information is limited. For a few, the clinical significance— the potential to cause reduced survival of transfused antigen-positive red blood cells, a hemolytic transfusion reaction (e.g., anti-AnWj, anti-Emm), or hemolytic disease of the fetus and newborn (e.g., anti-Kg, anti-HJK)—has been documented. Many other specificities have so far been benign (e.g., anti-Csa, anti-M1).

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