Adsorption of cold agglutinins with rabbit red blood cells

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 34 , ISSUE 2 (June 2018) > List of articles

Adsorption of cold agglutinins with rabbit red blood cells

Adam Cobaugh *

Keywords : cold agglutinin, rabbit red blood cells, rabbit erythrocyte stroma, RESt

Citation Information : Immunohematology. Volume 34, Issue 2, Pages 46-48, DOI: https://doi.org/10.21307/immunohematology-2018-008

License : (Transfer of Copyright)

Published Online: 16-October-2019

ARTICLE

ABSTRACT

Cold-reactive autoagglutinins may mask the presence of underlying clinically significant alloantibodies. Adsorption with rabbit red blood cells (RBCs) or stroma can remove cold autoagglutinins found in the patient’s plasma/serum that are directed towards antigens expressed on the surface of rabbit RBCs. By removing these cold autoagglutinins, it is then possible to determine whether any underlying alloantibody reactivity is present. Although this method may also unintentionally adsorb alloantibodies directed towards antigens found on rabbit RBCs, it is still a widely used and convenient method to remove cold autoagglutinins.

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