Low-ionic-strength saline solution–antiglobulin test (LISS-AGT)

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 34 , ISSUE 2 (June 2018) > List of articles

Low-ionic-strength saline solution–antiglobulin test (LISS-AGT)

LeeAnn Walker *

Keywords : low-ionic-strength saline, LISS, antiglobulin test, LISS-AGT, antibody detection, enhancement

Citation Information : Immunohematology. Volume 34, Issue 2, Pages 57-60, DOI: https://doi.org/10.21307/immunohematology-2018-010

License : (Transfer of Copyright)

Published Online: 16-October-2019

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ABSTRACT

The use of low-ionic-strength saline (LISS) solution as an enhancement for antibody screening and crossmatching was first described by Löw and Messeter in 1974. This method allowed for a reduced incubation time while maintaining adequate specificity and sensitivity of the antiglobulin test (AGT). Since then, the LISS-AGT tube method has been widely used in antibody detection and identification, as well as compatibility testing. As initially described, the method used red blood cells suspended in LISS. Modifications of the method led to development of the commercially prepared LISS additive solutions in use today. The LISS-AGT can be used effectively to detect alloantibodies of all major blood groups in antibody detection, antibody identification, and crossmatching procedures.

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