Use of the prewarm method for detecting clinically significant alloantibodies in the presence of cold autoantibodies

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 34 , ISSUE 4 (December 2018) > List of articles

Use of the prewarm method for detecting clinically significant alloantibodies in the presence of cold autoantibodies

Stephanie Dupuis *

Keywords : cold autoantibodies, clinically significant antibodies, prewarm method, blood type discrepancy

Citation Information : Immunohematology. Volume 34, Issue 4, Pages 148-150, DOI: https://doi.org/10.21307/immunohematology-2018-023

License : (Transfer of Copyright)

Accepted: 24-January-2021 / Published Online: 16-October-2019

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ABSTRACT

The prewarm (PW) method is useful for detecting and identifying clinically significant antibodies that bind to red blood cells and complement at 37°C and for avoiding antibodies that bind at temperatures less than 37°C. Antibodies that bind at temperatures less than 37°C are often cold autoantibodies that may be present in the serum of healthy individuals and are usually not clinically significant. The PW method is useful when these cold autoantibodies have a wide thermal range and interfere with standard testing methods by reacting at the 37°C and antihuman globulin test phases. When using the PW method, it is important to identify underlying, potentially clinically significant alloantibodies during pretransfusion testing to ensure the most appropriate component will be selected for transfusion.

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