Cold autoadsorption

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 34 , ISSUE 4 (December 2018) > List of articles

Cold autoadsorption

Ernest M. Ekema *

Keywords : cold autoadsorption, cold-reactive autoantibodies, autologous red blood cells, proteolytic enzymes

Citation Information : Immunohematology. Volume 34, Issue 4, Pages 158-160, DOI: https://doi.org/10.21307/immunohematology-2018-025

License : (Transfer of Copyright)

Published Online: 16-October-2019

ARTICLE

ABSTRACT

Cold-reactive autoantibodies can mask the presence of underlying clinically significant alloantibodies in a patient’s plasma or serum. These autoantibodies are problematic when performing laboratory procedures such as ABO typing, red blood cell (RBC) crossmatching, antibody detection testing, and antibody identification. To avert the masking of clinically significant alloantibodies in a patient’s plasma or serum, adsorption studies can be performed at 4°C using autologous RBCs if the patient has not been recently transfused.

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