How to recognize and resolve reagentdependent reactivity: a review

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 32 , ISSUE 3 (September 2016) > List of articles

How to recognize and resolve reagentdependent reactivity: a review

Gavin C. Patch / Charles F. Hutchinson / Nancy A. Lang * / Ghada Khalife

Keywords : reagent-dependent reactivity, solid-phase red blood cell adherence, gel, LISS, antibody identification, falsepositive reactions, panreactivity

Citation Information : Immunohematology. Volume 32, Issue 3, Pages 96-99, DOI: https://doi.org/10.21307/immunohematology-2019-052

License : (Transfer of Copyright)

Published Online: 09-October-2019

ARTICLE

ABSTRACT

Reagent-dependent reactivity can be described as agglutination of red blood cells (RBCs) in serologic testing that is not related to the interaction of RBC antigens and antibodies that the test system is intended to detect. In other words, reagent-dependent reactivity results in false-positive agglutination reactions in serologic testing. These false-positive reactions can cause confusion in antigen typing and RBC antibody detection and identification procedures, and may result in delays in patient transfusion. It is imperative that reagent-dependent reactivity is recognized and resolved during the investigation of ABO discrepancies, positive RBC antibody screens and antibody identification panels, and crossmatch reactivity.

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