Transfusion-related acute lung injury in an era of TRALI  risk mitigation

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 31 , ISSUE 4 (December 2015) > List of articles

Transfusion-related acute lung injury in an era of TRALI  risk mitigation

John C. Lavelle / Michelle L. Grant / Julie K. Karp *

Keywords : TRALI, AB plasma

Citation Information : Immunohematology. Volume 31, Issue 4, Pages 155-158, DOI: https://doi.org/10.21307/immunohematology-2019-085

License : (Transfer of Copyright)

Published Online: 26-October-2019

ARTICLE

ABSTRACT

Transfusion-related acute lung injury (TRALI) is a rare complication of transfusion, for which the true incidence remains obscure, since there are a number of factors that may lead to misdiagnosis. Despite this, it continues to be the leading cause of transfusion-associated mortality. Here we present a historical case of TRALI in an elderly female who received group AB plasma and discuss how current mitigation strategies would likely have prevented its occurrence. It is important to remember that both immune and non-immune factors play a role in TRALI pathogenesis, and although current preventative strategies may decrease TRALI’s incidence, they likely will not eliminate it.

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