Weak D type 67 in four related Canadian blood donors

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 31 , ISSUE 4 (December 2015) > List of articles

Weak D type 67 in four related Canadian blood donors

Philip Berardi / Emma Bessette / Michiko Ng / Nancy Angus / Debra Lane / Lise Gariepy / Katerina Pavenski / Gorka Ochoa-Garay / Jacqueline Cote / Mindy Goldman

Keywords : RHD variant, alloimmunization, weak D

Citation Information : Immunohematology. Volume 31, Issue 4, Pages 159-162, DOI: https://doi.org/10.21307/immunohematology-2019-086

License : (Transfer of Copyright)

Published Online: 26-October-2019

ARTICLE

ABSTRACT

Correct donor D typing is critical to prevent recipient alloimmunization. No method can detect all variants, and the immunogenicity of many variants is unknown. Routine ABO and D serologic typings are performed in our laboratory by automated microplate testing. Until 2011, routine confirmation of D– status of first-time donors was performed by the manual tube indirect antiglobulin test (IAT); this was replaced by automated solidphase testing including weak D testing by IAT. Selected donors are investigated by other methods. We describe four weak D type 67 (RHD*01W.67) donors whose samples tested as D– by automated microplate and manual methods but were later determined to be D+ by automated solid-phase and RHD gene analysis. Solidphase serologic and molecular typing results of all four donors were identical. It was identified that the donors are of EnglishIrish descent; two are brothers and the others are cousins.  Transfusion of blood from one of these donors likely resulted in alloimmunization to D in one of three recipients tested since no other documented exposures were identified. Lookback studies determined that two other D– recipients were not alloimmunized.

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