Paternity evaluation in the presence of splits and crossreactive antigens

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 7 , ISSUE 2 (June 1991) > List of articles

Paternity evaluation in the presence of splits and crossreactive antigens

Robert W. Gutendorf / Kamala Balakrishnan / David L. Taylor / Kelly Cox

Citation Information : Immunohematology. Volume 7, Issue 2, Pages 43-45, DOI: https://doi.org/10.21307/immunohematology-2019-1010

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Published Online: 14-December-2020

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ABSTRACT

Evaluation of paternity (alleged father, mother, and child) can range from a strightforward resolution to a complex problem that cannot be resolved without family studies. We present a case of disputed paternity in which tests for crossreactive groups (CREGs) and antigen subtypes (splits) within the human leukocyte antigen (HLA) system could not be used confidently to prove or disprove paternity. Further analysis, red cell enzyme tests, enabled a final verdict and confirmed the current reliability of HLA antisera defining splits.

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