Major non-ABO incompatibility caused by anti-Jka in a patient before allogeneic hematopoietic stem cell transplantation

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 29 , ISSUE 1 (March 2013) > List of articles

Major non-ABO incompatibility caused by anti-Jka in a patient before allogeneic hematopoietic stem cell transplantation

Miriam Y. Kim / Preeti Chaudhary / Ira A. Shulman / Vinod Pullarkat

Keywords : anti-Jka, major incompatibility, hematopoietic stem cell transplantation

Citation Information : Immunohematology. Volume 29, Issue 1, Pages 11-14, DOI: https://doi.org/10.21307/immunohematology-2019-117

License : (Transfer of Copyright)

Published Online: 01-December-2019

ARTICLE

ABSTRACT

A 49-year-old white man with blood group AB, D+ was found to have alloanti-Jka and -K when he developed a delayed hemolytic transfusion reaction before allogeneic hematopoietic stem cell transplant (HSCT). Given that his stem cell donor was blood group O, D+, Jk(a+), K–, rituximab was added to his conditioning regimen of fludarabine and melphalan to prevent hemolysis of engrafting Jk(a+) donor red blood cells. The patient proceeded to receive a peripheral blood stem cell transplant from a matched unrelated donor with no adverse events. To our knowledge, this is the first case of successful management of major non-ABO incompatibility caused by anti-Jka in a patient receiving an allogeneic HSCT reported in the literature.

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