A review of the JR blood group system

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 29 , ISSUE 2 (June 2013) > List of articles

A review of the JR blood group system

Lilian Castilho / Marion E. Reid

Keywords : blood groups, JR, ABCG2, BCRP, Jra antigen

Citation Information : Immunohematology. Volume 29, Issue 2, Pages 63-68, DOI: https://doi.org/10.21307/immunohematology-2019-126

License : (Transfer of Copyright)

Published Online: 01-December-2019

ARTICLE

ABSTRACT

The JR blood group system (ISBT 032) consists of one antigen, Jra, which is of high prevalence in all populations. The rare Jr(a–) phenotype has been found mostly in Japanese and other Asian populations, but also in people of northern European ancestry, in Bedouin Arabs, and in one Mexican. Anti-Jra has caused transfusion reactions and is involved in hemolytic disease of the fetus and newborn. The Jra antigen is located on ABCG2 transporter, a multipass membrane glycoprotein (also known as the breast cancer resistance protein, BCRP), which is encoded by the ABCG2 gene on chromosome 4q22.1. The Jr(a–) phenotype mostly results from recessive inheritance of ABCG2 null alleles caused by frameshift or nonsense changes.

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