The Diego blood group system: a review

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 29 , ISSUE 2 (June 2013) > List of articles

The Diego blood group system: a review

Dolores Figueroa

Keywords : Diego, AE1 protein, band 3, SLC4A1

Citation Information : Immunohematology. Volume 29, Issue 2, Pages 73-81, DOI: https://doi.org/10.21307/immunohematology-2019-128

License : (Transfer of Copyright)

Published Online: 01-December-2019

ARTICLE

ABSTRACT

The Diego blood group system (DI) currently encompasses 22 antigens. Three of the antigens are of high prevalence and the other 19 are of low prevalence. The antigens of the Diego blood group system are carried on the erythroid band 3 protein anion exchanger 1 (AE1), the product of a single gene, SLC4A1 (solute carrier family 4, anion exchanger, member 1). AE1 is a member of a family of three anion exchangers or transporters expressed in a variety of tissues. This protein is involved in carbon dioxide transport from tissues to lungs. It is also found in the kidney, where it is involved in acid secretion. Antibodies to Diego system antigens with the exception of anti-Dia, -Dib, -Wra, -ELO and -DISK do not seem to be of clinical significance for transfusion or of importance in hemolytic disease of the fetus and newborn.

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