American National Red Cross
Subject: Medical Laboratory Technology
ISSN: 0894-203X
eISSN: 1930-3955
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Adair Seager / S. Gerald Sandler
Keywords : Rh alloimmunization, anti-D, D+ RBCs, progenitor cell transplantation, solid-organ transplantation
Citation Information : Immunohematology. Volume 29, Issue 3, Pages 110-114, DOI: https://doi.org/10.21307/immunohematology-2019-133
License : (Transfer of Copyright)
Published Online: 01-December-2019
A review of the published literature on Rh alloimmunization reveals that its incidence varies with the volume of infused D+ red blood cells (RBCs), the probable Rh genotype of the RBCs, and the immune competency of the D– recipient. Among the reports of Rh alloimmunization in different clinical circumstances, we identified five studies in which a combined total of 62 D– recipients of hematopoietic stem cell or solid-organ transplants were transfused with D+ RBCs and none (0%) formed anti-D. The observation that immunosuppressive protocols developed to prevent rejection of tissue and organ transplants also prevented alloimmunization to the D blood group antigen raises the possibility of practical applications in blood transfusion practice.