Alloimmunization to the D antigen by a patient with weak D type 21

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 26 , ISSUE 1 (March 2010) > List of articles

Alloimmunization to the D antigen by a patient with weak D type 21

Heather McGann / Robert E. Wenk

Keywords : alloimmunization, anti-D, RHD gene, weak D

Citation Information : Immunohematology. Volume 26, Issue 1, Pages 27-29, DOI: https://doi.org/10.21307/immunohematology-2019-197

License : (Transfer of Copyright)

Published Online: 12-March-2020

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ABSTRACT

Antibodies of apparent D specificity may be found in D+ patients. We report a D+, multi-transfused Caucasian woman with myelodysplasia who exhibited several alloantibodies. One antibody was a moderately strong (2+) anti-D that persisted for 9 months, until the woman died. Molecular analysis of the patient’s RHD gene identified the rare weak D type 21 (938C>T) allele. D alloantibodies do not occur in patients with most weak D types, but some patients with a weak D phenotype, including those with type 21, can produce antibodies to nonself epitopes of the wild-type D antigen.

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