Clinical evaluation for lymphoproliferative disease prompted by finding of IgM warm autoanti-IT in two cases

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 25 , ISSUE 2 (June 2009) > List of articles

Clinical evaluation for lymphoproliferative disease prompted by finding of IgM warm autoanti-IT in two cases

Regina M. Leger / Frederick Lowder / Maria C. Dungo / Weip Chen / Holli M. Mason / George Garratty

Keywords : IgM warm autoantibody, autoanti-IT, hemolytic anemia

Citation Information : Immunohematology. Volume 25, Issue 2, Pages 60-62, DOI: https://doi.org/10.21307/immunohematology-2019-232

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Published Online: 17-March-2020

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ABSTRACT

Anti-IT is an unusual specificity originally described as a naturally occurring cold agglutinin. The antibody reacts strongly with cord RBCs, weakly with adult I RBCs, and most weakly with the rare adult i RBCs. IgG anti-IT in patients with hemolytic anemia has been associated with Hodgkin’s lymphoma. Difficulties in blood grouping tests and the presence of a warm reactive agglutinin in samples from two patients with hemolytic anemia led to further serologic studies and the identification of anti-IT. In both cases, the anti-IT was a rarely encountered IgM warm reactive agglutinin; in one case, the IgG component was also anti-IT, whereas in the second case the IgG antibody was broadly reactive. The unusual serologic finding of anti-IT prompted further clinical evaluation for lymphoproliferative disease in these two patients.

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