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Citation Information : Immunohematology. Volume 23, Issue 4, Pages 158-160, DOI: https://doi.org/10.21307/immunohematology-2019-334
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Published Online: 01-April-2020
It is well known that certain combinations of alloantibodies are frequently found together. Patients with sickle cell disease (SCD) are mostly of African ancestry, and they may make anti-hrB. A transfusion of hrB– blood is often achieved by using e– (R2R2) RBCs; it is generally believed that hrB– patients readily make anti-E or a “broad-spectrum” anti-Rh34 (-HrB). We describe two multiply transfused D+ patients with SCD and a history of anti-hrB who subsequently produced antiD. This raises the question whether anti-hrB together with anti-D is a more common antibody combination than anti-hrB with anti-E or anti-Rh34.