Novel molecular basis of an Inab phenotype  

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 21 , ISSUE 2 (June 2005) > List of articles

Novel molecular basis of an Inab phenotype  

Kim Hue-Roye / Vivien E. Powell / Gita Patel / Debra Lane / Mariska Maguire / Amy Chung / Marion E. Reid

Keywords : Cromer blood group system, decayaccelerating factor, DAF, CD55, Inab

Citation Information : Immunohematology. Volume 21, Issue 2, Pages 53-55, DOI: https://doi.org/10.21307/immunohematology-2019-393

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Published Online: 21-April-2020

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ABSTRACT

The Cromer blood group system consists of ten high-prevalence and three low-prevalence antigens carried on decay-accelerating factor (DAF). DAF is found in the cell membranes of RBCs, granulocytes,platelets,and lymphocytes and is widely represented in other body tissues. Sequence analyses of DNA were performed on a blood sample from a 91-year-old Japanese woman whose serum contained an alloantibody to a high-prevalence antigen in the Cromer blood group system (anti-IFC). A blood sample from her daughter was also studied. Sequence analysis revealed a substitution of 508C>T in exon 4 of DAF in the proband. The proband’s daughter was heterozygous for 508C/T. This study describes an Inab phenotype in which the 508C>T nonsense mutation is predicted to change arginine at amino acid residue 136 to a stop codon. This change is in SCR 3 of DAF . This study reports on the molecular basis of a new proband with the Inab phenotype who had no history of intestinal disorders.

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