Drug-dependent antibodies with immune hemolytic anemia in AIDS patients

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 19 , ISSUE 1 (March 2003) > List of articles

Drug-dependent antibodies with immune hemolytic anemia in AIDS patients

Carlos A. González / Liliana Guzmán / Gabriela Nocetti

Keywords : drug-induced hemolytic anemia, drugdependent antibodies, AIDS, immune hemolytic anemia

Citation Information : Immunohematology. Volume 19, Issue 1, Pages 10-15, DOI: https://doi.org/10.21307/immunohematology-2019-467

License : (Transfer of Copyright)

Published Online: 14-October-2020

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ABSTRACT

We studied the presence of drug-dependent antibodies (D-DAbs) in 53 patients with AIDS who developed immune hemolytic anemia (IHA). We examined sera and eluates for the presence of D-DAbs. Drug antibodies were detected in 43.4 percent (23/53) of the patients with IHA. Antibodies to more than one drug were detected in 60.8 percent (14/23) of patients with drug-induced IHA (D-IHA). The DAT was positive by RBC-bound IgG in eight patients, RBCbound IgG/C3d in nine, IgG/IgA in three, IgG/IgA/C3d in two, and one patient had RBC-bound C3d only. No drug-independent antibodies were detected. Our study demonstrates that patients with AIDS commonly develop D-DAbs. D-IHA should be included in the differential diagnosis of a falling Hb in AIDS patients receiving drugs.

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