Neonatal alloimmune thrombocytopenia due to anti-HPA-5b (Bra)

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 19 , ISSUE 4 (December 2003) > List of articles

Neonatal alloimmune thrombocytopenia due to anti-HPA-5b (Bra)

Sally A. Campbell-Lee / Deirdre DeSantis-Parsons / R. Sue Shirey / Thomas S. Kickler

Keywords : neonatal alloimmune thrombocytopenia (NAIT), HPA-5b, Bra

Citation Information : Immunohematology. Volume 19, Issue 4, Pages 127-131, DOI: https://doi.org/10.21307/immunohematology-2019-493

License : (Transfer of Copyright)

Published Online: 14-October-2020

ARTICLE

ABSTRACT

Neonatal alloimmune thrombocytopenia (NAIT) results from maternal immunization against fetal platelet antigens and can occur during the first pregnancy. The most common complications of NAIT are neonatal thrombocytopenia, intracerebral hemorrhage, and fetal death. Most cases of NAIT in Causasians are caused by anti-HPA-1a (PlA1). Anti-HPA-5b (Bra) accounts for only 4.3 percent of all NAIT cases. NAIT due to anti-HPA-5b is thought to be milder and have fewer complications than NAIT caused by anti-HPA-1a because of the lower number of HPA-5b antigenic sites per platelet. This report describes a severe case of NAIT due to anti-HPA-5b that was treated by intrauterine platelet transfusion.

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