Screening for RBC antibodies - what should we expect from antibody detection RBCs

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 18 , ISSUE 3 (September 2002) > List of articles

Screening for RBC antibodies - what should we expect from antibody detection RBCs

George Garratty

Keywords : antibody detection, low-frequency antigens, hemolytic transfusion reactions, hemolytic disease of the newborn, alloantibodies, antibody detection RBCs.

Citation Information : Immunohematology. Volume 18, Issue 3, Pages 71-77, DOI: https://doi.org/10.21307/immunohematology-2019-513

License : (Transfer of Copyright)

Published Online: 14-October-2020

ARTICLE

ABSTRACT

In the United States, the Food and Drug Administration mandates that red blood cells (RBCs) for antibody detection possess the following antigens: C, D, E, c, e, M, N, S, s, P1, Lea , Leb , K, k, Fya, Fyb, Jka, and Jkb. Although not required, it is generally agreed that homozygosity for C, D, E, c, e, Fya, and Jka is also preferable.There is no requirement for low-frequency antigens to be present.However, manufacturers of antibody detection RBCs receive requests for these RBCs to possess Cw, Kpa, and Wra.There are no data to support the considerable expense and effort involved in providing RBCs that possess low-frequency antigens such as Cw, Kpa, and Wra. The risk of clinically-significant hemolytic transfusion reactions occurring when such antibodies are not detected because antibody detection RBCs lack such antigens is about 1 in 500,000 to 1 in 1 million transfusions.

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