Nondetection of the S antigen due to the presence of sodium hypochlorite

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 18 , ISSUE 4 (December 2002) > List of articles

Nondetection of the S antigen due to the presence of sodium hypochlorite

Anne Long / Lyne Tremblay / Lucie Richard / Réal Lemieux / Mindy Goldman

Keywords : commercial saline, nondetection of S antigen, tube and microplate saline indirect antiglobulin tests

Citation Information : Immunohematology. Volume 18, Issue 4, Pages 120-122, DOI: https://doi.org/10.21307/immunohematology-2019-528

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Published Online: 14-October-2020

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ABSTRACT

Low concentrations of sodium hypochlorite (chlorine bleach) are known to destroy S antigen on intact fresh red blood cells (RBCs). Sodium hypochlorite is commonly used as a disinfectant. We report nondetection of the S antigen in tube and microplate saline indirect antiglobulin testing (SIAT) with a lot of commercial saline utilized in our donor screening and reference laboratories. Known S+s+ RBCs were found to be nonreactive with anti-S by SIAT in our reference laboratory. Our investigation demonstrated the presence of chlorine in the commercial saline. The saline lot was used for several days of donor screening and recall of FFP and platelet concentrates was initiated. Two lots of saline were recalled from blood banks across North America.

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