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Keywords : leukemia, erythrocytes, antigens, mutation, ABO blood group system, Rh blood group system, MNS blood group system, Lewis blood group system, I blood group collection, chromosome abnormalities
Citation Information : Immunohematology. Volume 17, Issue 1, Pages 1-9, DOI: https://doi.org/10.21307/immunohematology-2019-533
License : (Transfer of Copyright)
Published Online: 14-October-2020
Red blood cell (RBC) antigens represent inherited traits and as such, their expression should be constant throughout the life of an individual. We describe a patient in whom the expression of the Rh D and C antigens was lost due to the development of chronic myelogenous leukemia (CML). For this patient, this represented more than a blood bank curiosity but was of critical importance in determining further treatment of the leukemia. The mechanisms behind changes in RBC antigens due to malignancy are reviewed for a number of antigens, antigen systems, and antigen collections. Previous case reports of RBC antigen changes due to malignancy are summarized.