One thousand seventy antibodies detected only by a 2-stage papain test: wanted and unwanted positive reactions

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 17 , ISSUE 4 (December 2001) > List of articles

One thousand seventy antibodies detected only by a 2-stage papain test: wanted and unwanted positive reactions

Carmen Martin-Vega / Dolores Castella / Joan Cid / Marta Panadés

Keywords : antibody detection, enzyme-only antibodies

Citation Information : Immunohematology. Volume 17, Issue 4, Pages 122-124, DOI: https://doi.org/10.21307/immunohematology-2019-565

License : (Transfer of Copyright)

Published Online: 14-October-2020

ARTICLE

ABSTRACT

Despite the wide use of the antibody detection test for unexpected antibodies, controversy still remains regarding the use of enzymetreated red blood cells. Over a 6-year period, 72,573 samples from 49,863 patients submitted for pretransfusion compatibility testing were examined for unexpected antibodies. The antibody detection tests included a low-ionic-strength solution (LISS) indirect antiglobulin test and a two-stage papain (2SP) test. One thousand and seventy of the 2267 (47%) antibodies tested by 2SP were reactive only by the 2SP test. Overall, the 2SP test detected only 0.6% of antibodies considered to be clinically significant (10 examples of anti-c and 2 examples of anti-e). The slight additional safety provided by detection of clinically-significant antibodies is overshadowed by the high number of clinically-insignificant antibodies detected by the 2SP test.

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