Significant ABO hemolytic disease of the newborn in a group B infant with a group A2 mother

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 16 , ISSUE 3 (September 2000) > List of articles

Significant ABO hemolytic disease of the newborn in a group B infant with a group A2 mother

Hye-Ran Jeon / Beverly E.W. Calhoun / Mohammad Pothiawala / Marguerite Herschel / Beverly W. Baron

Keywords : ABO HDN, IgG anti-A and anti-B, group A2 mothers

Citation Information : Immunohematology. Volume 16, Issue 3, Pages 105-108, DOI: https://doi.org/10.21307/immunohematology-2019-587

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Published Online: 18-October-2020

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ABSTRACT

ABO hemolytic disease of the newborn (HDN) occurs almost exclusively in infants of blood group A or B who are born to group O mothers because IgG anti-A or -B occurs more commonly in group O than in group A or B individuals. We report a case in which clinically significant ABO-HDN occurred in a group B neonate from anti-B of a group A2 mother. The IgG anti-B titer was much higher (256) than that found in a group A1 mother/infant control group (≤ 32). The maternal antibody screen was negative and antibodies to low-frequency antigens were not detected. Therefore, when evaluating unexplained HDN in a group B newborn of a group A mother, it may be relevant to determine the subgroup of the mother. As presented here, anti-B from a group A2 mother may, on occasion, be responsible for HDN.

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