Quantitation of red cell-bound immunoglobulins and complement in lymphoma patients

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 16 , ISSUE 4 (December 2000) > List of articles

Quantitation of red cell-bound immunoglobulins and complement in lymphoma patients

M. Podberezin / A. Levina / L. Romanova / O. Margolin / O. Nasibov / A.V. Pivnik

Keywords : autoimmune hemolytic anemia (AIHA), enzyme-linked immunosorbent assay (ELISA), red blood cell (RBC), immunoglobulins (Ig), complement

Citation Information : Immunohematology. Volume 16, Issue 4, Pages 147-153, DOI: https://doi.org/10.21307/immunohematology-2019-597

License : (Transfer of Copyright)

Published Online: 18-October-2020

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ABSTRACT

Quantitative ELISA may be useful for determining the amount of red blood cell (RBC)-associated immunoglobulins (Igs) in patients with autoimmune hemolytic anemia (AIHA). In idiopathic AIHA, there is about 20 times more RBC-associated IgG and complement than in normal persons. In patients with low-grade lymphomas (particularly, B-CLL and splenic marginal zone lymphoma) autoimmune hemolysis is a component of their anemia. In highgrade malignant lymphomas (i.e, diffuse large B-cell lymphoma and peripheral T-cell lymphoma), as well as in Hodgkin’s disease, autoimmune hemolysis contributes little, if any, anemia. The quantitative ELISA for RBC-associated IgG and complement is useful for following the effects of treatment in patients with immune hemolysis.

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