Hemochromatosis, iron, and blood donation: a short review

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 15 , ISSUE 3 (September 1999) > List of articles

Hemochromatosis, iron, and blood donation: a short review

Angela C. Fields / Alfred J. Grindon

Keywords : hemochromatosis, blood donation, iron overload, donor screening, HFE gene

Citation Information : Immunohematology. Volume 15, Issue 3, Pages 108-112, DOI: https://doi.org/10.21307/immunohematology-2019-628

License : (Transfer of Copyright)

Published Online: 26-October-2020

ARTICLE

ABSTRACT

Hereditary hemochromatosis (HH), an autosomal recessive disease of iron overload, is one of the most common inherited diseases. The candidate gene (HFE) for HH has been identified recentIy and a DNA-based test for the mutation is available. Treatment for HH patients with elevated iron stores include repeated phlebotomy. Left untreated, iron overload can lead to cirrhosis, organ failure, and a shortened life expectancy. In the past and present, blood collected for therapeutic purposes from patients with HH has been discarded. The aim of this article is to address whether blood collected from HH patients should be used for allogeneic transfusion in the future.

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