Warm autoimmune hemolytic anemia associated with an IgM autoanti-Ge

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 14 , ISSUE 1 (March 1998) > List of articles

Warm autoimmune hemolytic anemia associated with an IgM autoanti-Ge

Thom S. Sererat / Douglas W. Veidt / Patricia A. Arndt / George Garratty

Keywords : autoimmune hemolytic anemia, warm autoanti-Gerbich, IgM autoantibody

Citation Information : Immunohematology. Volume 14, Issue 1, Pages 26-29, DOI: https://doi.org/10.21307/immunohematology-2019-650

License : (Transfer of Copyright)

Published Online: 03-November-2020

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ABSTRACT

A 28-year-old male with a prior history of Hodgkin’s disease and a recent upper respiratory tract infection presented with autoimmune hemolytic anemia (AIHA). The patient’s red blood cells (RBCs) were spontaneously agglutinated after room temperature and 37°C washes. Dithiothreitol-treated RBCs reacted strongly with anti-C3 and were nonreactive with anti-IgG, -IgM, and -IgA; they reacted with anti-IgM (κ light chains only) by flow cytometry. The patient’s serum was nonreactive. An acid eluate was only weakly reactive, but a 56°C heat eluate strongly agglutinated untreated RBCs (3+). Ficin-treated RBCs were nonreactive. En(a−) RBCs were strongly reactive, but Ge− RBCs were nonreactive. The anti-Ge in the eluate was IgM. The patient’s untreated RBCs were shown, by flow cytometry, to be weakly Ge+. This is the first report of IgM-mediated warm AIHA associated with autoanti-Ge.

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