Frequency of neutrophil-specific antigens among Koreans using the granulocyte indirect immunofluorescence test (GIFT)

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 13 , ISSUE 1 (March 1997) > List of articles

Frequency of neutrophil-specific antigens among Koreans using the granulocyte indirect immunofluorescence test (GIFT)

Kyou S. Han / Tae H. Um

Citation Information : Immunohematology. Volume 13, Issue 1, Pages 15-16, DOI: https://doi.org/10.21307/immunohematology-2019-694

License : (Transfer of Copyright)

Published Online: 09-November-2020

ARTICLE

ABSTRACT

NA1, NA2, NB1, NB2, NC1, and NE1 are a group of antigens specifically expressed on neutrophils. Antibodies against neutrophil-specific antigens are involved in alloimmune neonatal neutropenia (ANN), autoimmune neutropenia (AIN), and transfusion-related acute lung injury (TRALI). We investigated the frequencies of NA1, NA2, NB1, and Mart antigens in 105 healthy Korean blood donors (65 males, 40 females) by the granulocyte indirect immunofluorescence test (GIFT) employing flow cytometry. Antigen and gene frequencies were: NA1, 0.78 and 0.53, respectively; NA2, 0.75 and 0.50, respectively; and NB1, 0.86 and 0.62, respectively. The Mart antigen was positive in all 105 subjects included in this study. The proportions of NB1-positive neutrophils among NB1-positive individuals were variable with a mean value of 72.0 ± 20.2% (range, 27–100%). Differences in the frequency of the NA1 antigen have been reported between Asian and Caucasian populations. Our data support this variation. In addition, it was found that the frequency of the NA1 antigen in Koreans is significantly lower than in Japanese and Chinese populations (p < 0.05).

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