Antibodies to low-incidence antigens and elimination of the antihuman globulin phase of the crossmatch - case report: anti-Wra

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 13 , ISSUE 1 (March 1997) > List of articles

Antibodies to low-incidence antigens and elimination of the antihuman globulin phase of the crossmatch - case report: anti-Wra

Scott C. Wise / Patricia J. Larison / Lloyd O. Cook

Citation Information : Immunohematology. Volume 13, Issue 1, Pages 20-22, DOI: https://doi.org/10.21307/immunohematology-2019-696

License : (Transfer of Copyright)

Published Online: 09-November-2020

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ABSTRACT

An antibody to a low-incidence antigen was identified in the serum of a nontransfused male patient. The antibody was subsequently identified as anti-Wra and was only detectable at the antihuman globulin (AHG) phase of the crossmatch. Instances of severe hemolytic transfusion reactions have been reported following the transfusion of red blood cells containing low-incidence antigens in patients with antibodies directed toward these antigens (e.g., antiWra, -Cob, -Jsa, etc.). Elimination of the AHG phase of the crossmatch can result in either risks or benefits. Since patients seen at this facility primarily have been multitransfused or are multiparous females, the AHG phase of the crossmatch has been maintained.

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