Common variable immunodeficiency: diagnosis by absent ABO reverse type

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 13 , ISSUE 3 (September 1997) > List of articles

Common variable immunodeficiency: diagnosis by absent ABO reverse type

Carmen J. Julius / Mindy Wade / Abdul Waheed / Donald L. McNeil / Melanie S. Kennedy

Keywords : common variable immunodeficiency, ABO typing, isohemagglutinins, ABO discrepancy, immunoglobulin

Citation Information : Immunohematology. Volume 13, Issue 3, Pages 80-83, DOI: https://doi.org/10.21307/immunohematology-2019-712

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Published Online: 09-November-2020

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ABSTRACT

Many causes for ABO discrepancy between red blood cell and serum testing have been cited in the literature. ABO discrepancy due to weak or absent reverse type is most often seen at the extremes of age. We report a case of ABO discrepancy in a 25-year-old woman who presented for wisdom teeth extraction. Initial serologic workup revealed total absence of isohemagglutinin anti-B in this group A, D+ individual. Further evaluation revealed decreased levels of all classes of immunoglobulins and a medical history significant for multiple episodes of infection. Based on the patient’s history and laboratory data, she was diagnosed with common variable immunodeficiency (CVID). CVID can cause ABO discrepancy in an adult patient because of an absent ABO reverse type.

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