Anti-Holley detected in a primary immune response

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 12 , ISSUE 2 (June 1996) > List of articles

Anti-Holley detected in a primary immune response

Vicki J. Barrett / M. Margaret O’Brien / John J Moulds / Peggy Spruell / Valerie Jackson / James R. Stubbs

Citation Information : Immunohematology. Volume 12, Issue 2, Pages 62-65, DOI: https://doi.org/10.21307/immunohematology-2019-747

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Published Online: 10-November-2020

ARTICLE

ABSTRACT

Anti-Holley (Hy) has been reported as an IgG antibody occurring in previously transfused or multiparous black patients. In this case antiHy was identified in a 16-year-old black, primigravida female admitted at 32 weeks gestation because of premature rupture of the membranes. On admission, her blood type was determined to be A2B, D-positive and an antibody screen was negative. A second antibody screen, performed 4 days later, was positive in all three cells. Anti-Hy was subsequently identified. The antibody was reactive at room temperature, 37°C, and in the antiglobulin phase. IgG and IgM components of anti-Hy were demonstrated in the maternal serum, documenting a primary immune response. This resulted in serologic findings not previously described for anti-Hy. A direct antiglobulin test on the newborn red cells was negative and there was no clinical evidence of hemolytic disease of the newborn (HDN). A monocyte monolayer assay performed with maternal serum yielded negative results. Recent scientific information has resulted in the placement of Hy in the Dombrock blood group system. Alloantibodies to Dombrock system antigens have not been associated with severe HDN.

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