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Citation Information : Immunohematology. Volume 11, Issue 1, Pages 14-17, DOI: https://doi.org/10.21307/immunohematology-2019-780
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Published Online: 17-November-2020
A 39-year-oId Grenadian multiparous patient presented in the 12th week ofpregnancy. Her red cells were found to have the rare Cr(a-)
(ISBT Number 202001) phenotype within the Cromer complex, and her serum contained anti-Cra. To date, anti-Cra has not been implicated in hemolytic disease of the newborn (HDN), but there are very few published reports on this topic. This case provided an excellent opportunity for study. The patient’s serum showed no detectable functional activity in in vitro antibody-dependent, cell-mediated cytotoxicity assays, and no increase in the strength of the antibody during the pregnancy. The newborn infant showed no clinical signs of HDN, and was of normal weight. This case study suggests that anti-Cra is not implicated in HDN.