Correlation of monocyte monolayer assays and posttransfnsion survival of Yt(a+) red cells in patients with anti-Yta

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 11 , ISSUE 3 (September 1995) > List of articles

Correlation of monocyte monolayer assays and posttransfnsion survival of Yt(a+) red cells in patients with anti-Yta

Robert J. Eckrich / Delores M. Mallory / S. Gerald Sandler

Citation Information : Immunohematology. Volume 11, Issue 3, Pages 81-84, DOI: https://doi.org/10.21307/immunohematology-2019-795

License : (Transfer of Copyright)

Published Online: 17-November-2020

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ABSTRACT

Anti-Yta is an antibody to a high-frequency (99.8%) antigen and has been reported to have variable clinical significance. A retrospective review of monocyte monolayer assay (MMA) results on sera from 79 patients with anti-Yta was conducted to determine the reliability of this assay to predict the clinical significance of anti-Yta. Results of the MMA, other serological tests, and patient transfusion histories were analyzed. The MMA was found to be a reliable predictor of the clinical significance of anti-Yta when samples for analysis were collected at least six weeks after initial detection ofthe antibody. Only 18.2 percent of those examples of anti-Yta tested appeared to be clinically significant.

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