Fy3 and Sla are carried on different red cell membrane proteins

Publications

Share / Export Citation / Email / Print / Text size:

Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

GET ALERTS SUBSCRIBE

ISSN: 0894-203X
eISSN: 1930-3955

DESCRIPTION

4
Reader(s)
4
Visit(s)
0
Comment(s)
0
Share(s)

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue / page

Archive
Volume 37 (2021)
Volume 36 (2020)
Volume 35 (2019)
Volume 34 (2018)
Volume 33 (2017)
Volume 32 (2016)
Volume 31 (2015)
Volume 30 (2014)
Volume 29 (2013)
Volume 28 (2012)
Volume 27 (2011)
Volume 26 (2010)
Volume 25 (2009)
Volume 24 (2008)
Volume 23 (2007)
Volume 22 (2006)
Volume 21 (2005)
Volume 20 (2004)
Volume 19 (2003)
Volume 18 (2002)
Volume 17 (2001)
Volume 16 (2000)
Volume 15 (1999)
Volume 14 (1998)
Volume 13 (1997)
Volume 12 (1996)
Volume 11 (1995)
Volume 10 (1994)
Volume 9 (1993)
Volume 8 (1992)
Volume 7 (1991)
Volume 6 (1990)
Volume 5 (1989)
Volume 4 (1988)
Volume 3 (1987)
Related articles

VOLUME 9 , ISSUE 2 (June 1993) > List of articles

Fy3 and Sla are carried on different red cell membrane proteins

Joann M. Moulds

Citation Information : Immunohematology. Volume 9, Issue 2, Pages 50-52, DOI: https://doi.org/10.21307/immunohematology-2019-957

License : (Transfer of Copyright)

Published Online: 06-December-2020

ARTICLE

ABSTRACT

Fy3 and Sla are high-incidence antigens that are absent from the red cells of 60-70 percent of black individuals. The correspond­ing antibodies have similar serologic characteristics. Therefore, a study was undertaken to investigate whether Fy3 and Sla might be the same antigen. Red cells from donors shown to be Fy3+, Sl(a+) were labeled with 125I and detergent solubilized. The sol­ubilized membranes were immunoprecipitated with two examples of anti-Sla and four examples of anti-Fy3. The eluates were run on polyacrylamide gels under reducing or nonreducing con­ditions. The four examples of anti-Fy3 precipitated a protein of approximately 31 kDa, while the two examples of anti-Sla exhibit­ed a band at 220 kDa. Since the molecular weight of Fy3 is simi­lar to that reported for Fya, it is likely that Fy3 is carried on the same protein that expresses Fya and Fyb. However, Fy3 is distinct from the SIa antigen, which is known to be carried on comple­ment receptor one (CR1).

You don't have 'Full Text' access of this article.

Purchase Article Subscribe Journal Share