Neonatal testing leading to the identification of Bh (para-Bombay) phenotype in the mother: case report with review of the literature

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 37 , ISSUE 2 (Jun 2021) > List of articles

Neonatal testing leading to the identification of Bh (para-Bombay) phenotype in the mother: case report with review of the literature

G. Mohan * / A. Vaidya / S. Shastry

Keywords : blood groups, H antigen, anti-H, para-Bombay, blood group discrepancy, secretor test, India

Citation Information : Immunohematology. Volume 37, Issue 2, Pages 59-63, DOI: https://doi.org/10.21307/immunohematology-2021-008

License : (Transfer of Copyright)

Published Online: 25-June-2021

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ABSTRACT

Para-Bombay is a rare phenotype with a homozygous nonfunctional FUT1 gene and a normal FUT2 gene leading to H-deficient red blood cells (RBCs) with or without ABH substances, depending on inheritance of the ABO gene. This case is about a 5-day-old male baby suffering from sepsis who required a 45-mL packed RBC transfusion. The baby’s sample tested as A1B, D+ and mother’s sample tested as group O, D+ with group 4 discrepancy due to ABO isoagglutinins. Further workup of the mother’s sample with anti-H lectin was negative, which suggested the mother to be group Oh, D+. Antibody screening was panreactive with negative autocontrol, suggestive of anti-H. The titer of immunoglobulin (Ig)M anti-H was 64, IgG titer using dithiothreitol was 8, and anti-IH was absent. A negative adsorption and elution test suggested that RBCs were devoid of A and B antigens. The father’s sample tested clearly as group A1, D+; hence, the cis-AB blood group was ruled out in the baby. The secretor study of the mother’s saliva revealed the presence of B and H substances that neutralized polyclonal B and H antisera. Therefore, we concluded that the mother was of the para-Bombay (Bh) phenotype. This case highlights the importance of reverse grouping and resolving blood grouping discrepancies between mother and child―in this case because of an incongruous ABO blood type of the baby and the mother who was previously tested as group O, D+.

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