Magnetoelastic Biosentinels for the Capture and Detection of Low-Concentration Pathogens in Liquid

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International Journal on Smart Sensing and Intelligent Systems

Professor Subhas Chandra Mukhopadhyay

Exeley Inc. (New York)

Subject: Computational Science & Engineering, Engineering, Electrical & Electronic

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VOLUME 7 , ISSUE 5 (December 2014) > List of articles

Special issue ICST 2014

Magnetoelastic Biosentinels for the Capture and Detection of Low-Concentration Pathogens in Liquid

Shin Horikawa / Yating Chai / Howard C. Wikle / Bryan A. Chin

Keywords : biosentinel; phage; detection; pathogen

Citation Information : International Journal on Smart Sensing and Intelligent Systems. Volume 7, Issue 5, Pages 1-4, DOI: https://doi.org/10.21307/ijssis-2019-075

License : (CC BY-NC-ND 4.0)

Published Online: 15-February-2020

ARTICLE

ABSTRACT

This paper investigates phage-coated magnetoelastic (ME) biosentinels that capture and detect low-concentration pathogenic bacteria in stagnant liquid. These biosentinels are composed of a freestanding ME resonator platform coated with a landscape phage that specifically binds with the pathogens of interest. These biosentinels can be moved through a liquid by externally applied magnetic fields. When a time-varying magnetic field is applied, the ME biosentinels can be placed into mechanical resonance by magnetostriction. As soon as the biosentinels bind with the target pathogen through the phagebased biomolecular recognition, a change in the biosentinel's resonant frequency occurs, and thereby the presence of the target pathogen can be detected. Detection of Bacillus anthracis spores under stagnant flow conditions was demonstrated.

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REFERENCES

 [1] M. L. Johnson, J. Wan, S. Huang, Z. Cheng, V. A. Petrenko, D. Kim, B. A. Chin, “A wirelss biosensor using microfabricated phage-interfaced magnetoelastic particles,” Sensors and Actuators A: Physical, vol. 144, pp. 38–47, 2008. 

[2] S. Li, S. Horikawa, M. Park, Y. Chai, V. J. Vodyanoy, B. A. Chin, “Amorphous metallic glass biosensors,” Intermetallics, vol. 30, pp. 80– 85, 2012.

[3] C. Liang, S. Morshed, B. C. Prorok, “Correction for longitudinal mode vibration in thin slender beams,” Applied Physics Letters, vol. 90, p. 221912, 2007.

[4] Y. Chai, S. Li, S. Horikawa, M. Park, V. Vodyanoy,B. A. Chin, “Rapid and sensitive detection of Salmonella Typhimurium on eggshells by using wireless biosensors,” Journal of Food Protection, vol. 75, pp. 631– 636, 2012.

[5] Y. Chai, H. C. Wikle, Z. Wang, S. Horikawa, S. Best, Z. Cheng, D. F. Dyer, B. A. Chin, “Design of a surface-scanning coil detector for direct bacteria detection on food surfaces using a magnetoelastic biosensor,” Journal of Applied Physics, vol. 114, pp. 104504–104504-7, 2013.

[6] Y. Chai, S. Horikawa, H. C. Wikle, Z. Wang, B. A. Chin, “Surfacescanning coil detectors for magnetoelastic biosensors: A comparison of planar-spiral and solenoid coils,” Applied Physics Letters, vol. 103, pp. 173510–173510-4, 2013.

[7] Y. Chai, S. Horikawa, S. Li, H. C. Wikle, B. A. Chin, “A surfacescanning coil detector for real-time, in-situ detection of bacteria on fresh food surfaces,” Biosensors and Bioelectronics, vol. 50, pp. 311–317, 2013. 

[8] S. Horikawa, D. Bedi, S. Li, W. Shen, S. Huang, I. Chen, Y. Chai, M. L. Auad, M. J. Bozack, J. M. Barbaree, V. A. Petrenko, B. A. Chin, “Effects of surface functionalization on the surface phage coverage and the subsequent performance of phage-immobilized magnetoelastic biosensors,” Biosensors and Bioelectronics, vol. 26, pp. 2361–2367, 2011.

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