Detection of adsorbed cytochrome c on hydroxyapatite thick films using a microwave sensor


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International Journal on Smart Sensing and Intelligent Systems

Professor Subhas Chandra Mukhopadhyay

Exeley Inc. (New York)

Subject: Computational Science & Engineering, Engineering, Electrical & Electronic


eISSN: 1178-5608



VOLUME 7 , ISSUE 5 (December 2014) > List of articles

Special issue ICST 2014

Detection of adsorbed cytochrome c on hydroxyapatite thick films using a microwave sensor

M. Salazar-Alvarez / S.A.M. Tofail / E. Magner / O. Korostynska / A. Mason / A. Al-Shamma'a

Keywords : Protein detection, hydroxyapatite, microwave sensing, interdigitated electroe

Citation Information : International Journal on Smart Sensing and Intelligent Systems. Volume 7, Issue 5, Pages 1-4, DOI:

License : (CC BY-NC-ND 4.0)

Published Online: 15-February-2020



An interdigitated microwave sensor was used to detect the adsorption of cytochrome c on hydroxyapatite thick films. Changes in the microwave spectral response were indicative of the presence of adsorbed cytochrome c. The sensitivity of the system was also evaluated using different protein loadings on the e films. The results suggest that the microwave sensor can be utilized to detect protein.

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1. Koutsopoulos, S., Synthesis and characterization of hydroxyapatite crystals: A review study on the analytical methods. Journal of Biomedical Materials Research, 2002. 62(4): p. 600-612.

2. Tofail, S., et al., Direct and ultrasonic measurements of macroscopic piezoelectricity in sintered hydroxyapatite. Journal of Applied Physics, 2009. 105(6): p. 064103.

3. Lang, S.B., et al., Pyroelectric, piezoelectric, and photoeffects in hydroxyapatite thin films on silicon. Applied Physics Letters, 2011. 98(12): p. 123703-3.

4. Tofail, S., et al., Pyroelectric surface charge in hydroxyapatite ceramics. Journal of Applied Physics, 2009. 106(10): p. 106104.

5. Robin, S., et al., Charge Specific Protein Placement at Submicrometer and Nanometer Scale by Direct Modification of Surface Potential by Electron Beam. Langmuir, 2011. 27(24): p. 14968-14974.

6. Lampin, M., et al., Correlation between substratum roughness and wettability, cell adhesion, and cell migration. Journal of biomedical materials research, 1997. 36(1): p. 99-108.

7. Rechendorff, K., et al., Enhancement of Protein Adsorption Induced by Surface Roughness. Langmuir, 2006. 22(26): p. 10885-10888.

8. Dorozhkin, S.V., Bioceramics of calcium orthophosphates. Biomaterials, 2010. 31(7): p. 14651485.

9. Korostynska, O., et al. High temperature induced pyroelectricity in screen-printed Hydroxyapatite thick films. in Electrets (ISE), 2011 14th International Symposium on. 2011. IEEE.

10. Konaka, T., et al., Relative permittivity and dielectric loss tangent of substrate materials for high-T c superconducting film. Journal of Superconductivity, 1991. 4(4): p. 283-288.

11. Kim, H.T., et al., Low Temperature Sintering and Microwave Dielectric Properties of Zinc Metatitanate Rutile Mixtures Using Boron. Journal of the American Ceramic Society, 1999. 82(11): p. 3043-3048.

12. Korostynska, O., et al., Novel method for vegetable oil type verification based on real-time microwave sensing. Sens. Actuator A-Phys., 2013. 202(0): p. 211-216.

13. Mason, A., et al., A resonant co-planar sensor at microwave frequencies for biomedical applications. Sens. Actuator A-Phys., 2013. 202(0): p. 170-175.

14. Krupka, J., Frequency domain complex permittivity measurements at microwave frequencies. Measurement Science and Technology, 2006. 17(6): p. R55.

15. Sheen, J., Study of microwave dielectric properties measurements by various resonance techniques. Measurement, 2005. 37(2): p. 123-130.

16. Nyfors, E. and P. Vainikainen. Industrial microwave sensors. in Microwave Symposium Digest, 1991., IEEE MTT-S International. 1991. IEEE.

17. Korostynska, O., et al. Planar electromagnetic wave sensor for instantaneous assessment of pesticides in water. in Sensing Technology (ICST), 2013 Seventh International Conference on. 2013.

18. Völgyi, F., Microstrip Transmission- and ReflectionType Sensors Used in Microwave Aquametry, in Electromagnetic Aquametry, K. Kupfer, Editor. 2005, Springer Berlin Heidelberg. p. 243-256.

19. Korostynska, O., et al., Biomedical Sensing with Hydroxyapatite Ceramics in GHz Frequency Range. Key Engineering Materials, 2013. 543: p. 26-29.

20. Ow, Y.-L.P., et al., Cytochrome c: functions beyond respiration. Nature Reviews Molecular Cell Biology, 2008. 9(7): p. 532-542.