Etiologic Agents and Antifungal Susceptibility of Oral Candidosis from Romanian patients with HIV-infection or type 1 diabetes mellitus

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Polish Journal of Microbiology

Polish Society of Microbiologists

Subject: Microbiology

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ISSN: 1733-1331
eISSN: 2544-4646

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VOLUME 65 , ISSUE 1 (March 2016) > List of articles

Etiologic Agents and Antifungal Susceptibility of Oral Candidosis from Romanian patients with HIV-infection or type 1 diabetes mellitus

Bogdan Minea / Valentin Nastasa / Anna Kolecka / Magdalena Mares / Narcisa Marangoci / Irina Rosca / Mariana Pinteala / Monica Hancianu / Mihai Mares *

Keywords : antifungal susceptibility, MXP-4509, oral candidosis, Romanian HIV and diabetes patients

Citation Information : Polish Journal of Microbiology. Volume 65, Issue 1, Pages 123-129, DOI: https://doi.org/10.5604/17331331.1197327

License : (CC BY-NC-ND 4.0)

Received Date : 11-March-2015 / Accepted: 21-April-2015 / Published Online: 15-March-2016

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ABSTRACT

This is the first Romanian investigation of oral candidosis in patients suffering of HIV-infection or type 1 diabetes mellitus (T1DM).Candida albicans was the dominant species in both types of isolates: n = 14 (46.7%) in T1DM, n = 60 (69.8%) in HIV. The most frequent non-albicans Candida spp. were Candida kefyr (n = 6; 20%) in T1DM and Candida dubliniensis (n = 8; 9.3%) in HIV. Resistance to fluconazole was detected only in the HIV non-albicans Candida group (n = 8; 9.3%). All isolates were susceptible to VOR. The experimental drug MXP had MIC values equal or close to the ones of VOR. Echinocandin resistance was more frequent than azole resistance.

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