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  • Immunohematology

 

Article | 01-April-2020

Reduced red blood cell destruction by antibody fragments

period of the RBCs in the circulation. Direct injection of mouse RBC-specific Ter-119 monoclonal antibody into mice resulted in a more severe anemia compared with that in mice injected with the Ter-119 F(ab´)2 fragment. We found that mouse RBCs coated in vitro with the Ter-119 F(ab´)2 fragment, when transfused into mice,survived longer in circulation compared with RBCs coated with whole Ter-119 IgG molecule. The data support the conclusion that antibodies can be rendered less pathogenic

Amina Mqadmi, Steven Abramowitz, Xiaoying Zheng, Karina Yazdanbakhsh

Immunohematology, Volume 22 , ISSUE 1, 11–14

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