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Article | 16-October-2019

Use of the prewarm method for detecting clinically significant alloantibodies in the presence of cold autoantibodies

The prewarm (PW) method is useful for detecting and identifying clinically significant antibodies that bind to red blood cells and complement at 37°C and for avoiding antibodies that bind at temperatures less than 37°C. Antibodies that bind at temperatures less than 37°C are often cold autoantibodies that may be present in the serum of healthy individuals and are usually not clinically significant. The PW method is useful when these cold autoantibodies have a wide thermal range and

Stephanie Dupuis

Immunohematology, Volume 34 , ISSUE 4, 148–150

Review | 01-December-2019

Thermal amplitude test

The thermal amplitude test is performed to determine the reactivity of a cold autoantibody at varying temperatures: 4°C, 22°C, 30°C, and 37°C. Cold autoantibodies that are reactive at temperatures greater than 30°C have the potential to be clinically significant regardless of the antibody titer. Cold autoantibodies that are reactive at temperatures less than 30°C are not considered to be clinically significant.

Courtney Hopkins, Tiffany K. Walters

Immunohematology, Volume 29 , ISSUE 2, 49–50

Report | 12-March-2020

Determination of optimal method for antibody identification in a reference laboratory

-phase methods. Of the 254 samples tested, 115 showed agreement in antibody identification with all three methods. The tube method identified all but six clinically significant antibodies. The gel method did not identify 59 clinically significant antibodies. Fifty-six clinically significant antibodies were not identified by solid-phase testing. Tube testing identified 27 clinically insignificant antibodies, primarily cold autoantibodies. Gel and solid-phase methodologies identified two and three cold

Jennifer R. Haywood, Marilyn K. Grandstaff Moulds, Barbara J. Bryant

Immunohematology, Volume 27 , ISSUE 4, 146–150

Article | 22-January-2021

A case of megaloblastic anemia simulating a cold autoimmune hemolytic anemia

. Anti-I specificity was identified by testing the patient’s serum against adult OI RBCs, OI RBCs treated with ficin, Oi cord RBCs, autologous RBCs, and group O RBCs. Cold autoantibodies reacted more strongly with OI adult RBCs than with Oi cord RBCs. Anti-I titer was less than 64 at 4°C. Serum protein electrophoresis and immunoglobulin levels (IgM/IgG/IgA) were normal. T-receptor cell analysis of bone marrow (BM) was polyclonal. Lymphocyte immunophenotype assessed by flow cytometry was normal. Total

R. De La Puerta, N. Carpio, G. Sanz, P. Solves

Immunohematology, Volume 36 , ISSUE 3, 89–92

Case report | 01-December-2019

A case of masquerading alloantibodies:  the value of a multitechnique approach

Paula M.S. Wennersten, Laurie J. Sutor

Immunohematology, Volume 30 , ISSUE 3, 117–120

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