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  • Immunohematology

 

Review | 28-April-2020

Review: complement receptor 1 therapeutics for prevention of immune hemolysis

anemia (AIHA). Complement receptor 1 (CR1) is a large single-pass glycoprotein that is expressed on a variety of cell types in blood, including RBCs and immune cells. Among its multiple functions is its ability to inhibit complement activation. Furthermore, gene knockout studies in mice implicate a role for CR1 (along with the alternatively spliced gene product CR2) in prevention of autoimmunity. This review discusses the possibility that the CR1 protein may be manipulated to prevent and treat AIHA

Karina Yazdanbakhsh

Immunohematology, Volume 21 , ISSUE 3, 109–118

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