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Article | 01-April-2020

Reduced red blood cell destruction by antibody fragments

Antibodies to blood group antigens can cause immune RBC destruction directly (extravascular destruction) or indirectly through subsequent complement activation (intravascular hemolysis). The Fc portion of the IgG antibody is responsible for the effector functions of immune RBC destruction. We hypothesized that sensitization of RBCs with blood group antigen–specific IgG antibodies lacking their Fc portion would escape from the recipient’s immune system, allowing for a longer survival

Amina Mqadmi, Steven Abramowitz, Xiaoying Zheng, Karina Yazdanbakhsh

Immunohematology, Volume 22 , ISSUE 1, 11–14

Original Paper | 31-August-2018

Ultrasound image of malignant bone tumors in children. An analysis of nine patients diagnosed in 2011–2016

Tomasz Madej, Joanna Flak-Nurzyńska, Ewa Dutkiewicz, Anna Ciechomska, Jerzy Kowalczyk, Andrzej Paweł Wieczorek

Journal of Ultrasonography, Volume 18 , ISSUE 73, 103–111

Review Article | 30-March-2018

Diabetic foot syndrome: Charcot arthropathy or osteomyelitis? Part I: Clinical picture and radiography

osteopenia, lytic lesions, cortical destruction, periosteal reactions as well as, in the chronic phase, osteosclerosis and sequestra. Neurogenic arthropathy, however, presents an image resembling rapidly progressing osteoarthritis combined with aseptic necrosis or inflammation. The image includes: bone destruction with subluxations and dislocations as well as pathological fractures that lead to the presence of bone debris, osteopenia and, in the later phase, osteosclerosis, joint space narrowing

Aleksandra Konarzewska, Anna Korzon-Burakowska, Ludomira Rzepecka-Wejs, Iwona Sudoł-Szopińska, Edyta Szurowska, Michał Studniarek

Journal of Ultrasonography, Volume 18 , ISSUE 72, 42–49

Review | 15-May-2020

Review: immune thrombocytopenic purpura: an update for immunohematologists

Immune thrombocytopenic purpura (ITP) is an acquired disease in which autoantibodies to platelets cause their sequestration and destruction by mononuclear macrophages, principally in the spleen. If increased production of platelets by megakaryocytes does not compensate for platelet destruction, the number of circulating platelets decreases (thrombocytopenia), resulting in a characteristic bleeding tendency (purpura). While most children with the disease experience a relatively short and benign

S. Gerald Sandler

Immunohematology, Volume 20 , ISSUE 2, 112–117

Review | 01-April-2020

Transfusion of multiple units of Js(b+) red blood cells in the presence of anti-Jsb in a patient with sickleβ-thalassemia disease and a review of the literature

anti-Jsb. In addition to routine serologic methods to study the patient’s RBCs and plasma,a monocyte monolayer assay (MMA) was performed on the patient’s samples obtained 2 and 9 days after transfusion of the Js(b+) RBCs to determine the potential clinical significance of the anti-Jsb. Various laboratory parameters including quantitative hemoglobin fraction analyses were used to monitor for increased RBC destruction. The MMA reactivity of the patient’s anti-Jsb increased from 2.3

Shan Yuan, Nadia P. Ewing, Debra Bailey, Marissa Salvador, Shirong Wang

Immunohematology, Volume 23 , ISSUE 2, 75–80

case-report | 25-June-2021

Severe perinatal hemolytic disease due to anti-e

G. Soler-Noda, Y. Romero-Díaz, L. Orbeal-Aldama, S. Aquino-Rojas

Immunohematology, Volume 37 , ISSUE 2, 72–77

Review | 28-April-2020

Review: complement receptor 1 therapeutics for prevention of immune hemolysis

The complement system plays a crucial role in fighting infections and is an important link between the innate and adaptive immune responses. However, inappropriate complement activation can cause tissue damage, and it underlies the pathology of many diseases. In the transfusion medicine setting, complement sensitization of RBCs can lead to both intravascular and extravascular destruction. Moreover, complement deficiencies are associated with autoimmune disorders, including autoimmune hemolytic

Karina Yazdanbakhsh

Immunohematology, Volume 21 , ISSUE 3, 109–118

Article | 10-November-2020

Severe intravascular hemolysis due to autoantibodies stimulated by blood transfusion

Autoantibodies may cause severe hemolytic anemia, but only rarely are they the cause of a hemolytic transfusion reaction due to the destruction of transfused allogeneic blood. In two patients, autoantibody was detected shortly after blood transfusion. The first case was a D-negative patient who produced an autoanti-Ce and subsequently developed hemoglobinuria and hyperbilirubinemia. The second case was a patient who developed an autoanti-Wrb that caused severe hemolysis that resulted in death.

D. Chan, G.D. Poole, M. Binney, M.D. Hamon, J.A. Copplestone, A.G. Prentice

Immunohematology, Volume 12 , ISSUE 2, 80–83

Case report | 17-November-2020

Case report: a pregnant woman with immune thrombocytopenic purpura and unusual red cell antibodies

Maternal immune thrombocytopenic purpura (ITP) may lead to fetal platelet destruction. This process is mediated by IgG platelet autoantibodies that cross the placenta. In this case, not only were platelet autoantibodies present, but red cell alloantibodies anti-E, anti-M, and anti-He were also present. Anti-E, present as an IgG antibody, crossed the placenta, but did not cause clinical problems in the E+ newborn, other than possible hyperbilirubinemia that was treated by phototherapy.

Carmela R. Nanton, Sharon M. Martin, Lloyd O. Cook, Patricia J. Larison

Immunohematology, Volume 11 , ISSUE 4, 153–155

Article | 20-December-2020

An example of anti-JMH with characteristics of a clinically significant antibody

The authors studied an example of red cell anti-JMH (John Milton Hagen) that exhibited several characteristics of a possible clinically significant antibody able to cause red cell destruction in vivo. Strong serological reactivity, a positive monocyte monolayer assay, and immunoglobulin subclass determination as IgG3 all indicate possible ability to destroy red cells. A 51Cr-labeled red cell survival study was not done as the patient did not require red cell transfusions but may be recommended

John R. Geisland, Mary F. Corgan, Brenda L. Hillard

Immunohematology, Volume 6 , ISSUE 1, 9–11

Research Article | 27-February-2017


Summary. To improve the working conditions of the electric locomotive running part, it is necessary to decrease unsprung masses, lateral loads and the angle of attack and provide the third body with proper tribotechnical properties. A new scheme of the freight electric locomotive running gear is elaborated in the work, which ensures a decrease of unsprung masses, relative sliding of a wheel on the rail and an angle of attack that provides resistance to the destruction of the third body in the


Transport Problems, Volume 11 , ISSUE 3, 103–109

research-article | 07-January-2020


annually as a result of plastic pollution is at least USD 13 billion [23]. The destruction of waste polymers in the conditions of deposition at landfills is quite slow and this process is poorly understood. There are several types of destruction of polymeric waste placed on landfills: mechanical, photo-oxidative and biological. The degradation products of polymeric materials serve as the basis for the formation of a number of new chemical compounds, including toxic ones. Some of them (about 10%) remain

Elena GUBANOVA, Larisa KUPINETS, Hanna DEFORZH, Viktor KOVAL, Krzysztof GASKA

Architecture, Civil Engineering, Environment, Volume 12 , ISSUE 4, 99–108

Case report | 01-December-2019

Possible suppression of fetal erythropoiesis by the Kell blood group antibody anti-Kpa

Antibodies to antigens in the Kell blood group system are usually immunoglobulin G, and, notoriously, anti-K, anti-k, and anti-Kpa can cause severe hemolytic transfusion reactions, as well as severe hemolytic disease of the fetus and newborn (HDFN). It has been shown that the titer of anti-K does not correlate with the severity of HDFN because, in addition to immune destruction of red blood cells (RBCs), anti-K causes suppression of erythropoiesis in the fetus, which can result in severe anemia

Michelle Tuson, Kim Hue-Roye, Karen Koval, Sherwin Imlay, Rajendra Desai, Gayatri Garg, Esam Kazem, Diane Stockman, Janis S. Hamilton, Marion E. Reid

Immunohematology, Volume 27 , ISSUE 2, 58–60

Article | 09-August-2018


added to the activated sludge in case of a drop of nitrification efficiency. The study showed that even a four-year-old storage of nitrifying bacteria does not result in their complete destruction.  

Magdalena DOMAŃSKA, Kamila HAMAL, Małgorzata FRĄSZCZAK, Janusz ŁOMOTOWSKI

Architecture, Civil Engineering, Environment, Volume 9 , ISSUE 1, 113–118

Article | 06-December-2020

Effect of enzymes on and chemical modifications of high-frequency red cell antigens

Enzyme or chemical modification of intact red cells results in the destruction of some blood group antigens. The pattern of reactions of an antibody with red cells treated with various proteinases, with sialidase, and with the disulfide bond-reducing agent 2-aminoethylisothiouronium bromide (AET) can aid in antibody identification. This information can prove particularly beneficial with antibodies to antigens of very high frequency, where antigen-negative cells may be difficult to obtain

Geoff Daniels

Immunohematology, Volume 8 , ISSUE 3, 53–57

Research Article | 25-October-2017

Community gardens as pathways to community resilience? Reflections on a pilot study in Adelaide, South Australia

Cities across the world are facing increasing challenges from the impacts of urbanisation, pollution and climate change. Green spaces and urban vegetation are at ongoing risk of destruction or removal. New residential developments rarely plan for or provide gardens. Nonetheless, the need to maintain urban green spaces is more important than ever. This paper discusses the role of community gardens and whether or not they have a role to play in enhancing community resilience to issues such as


South Australian Geographical Journal, Volume 113 , 13–28

Article | 03-November-2020

GIL: a red cell antigen of very high frequency

disease. Anti-GIL may have been responsible for a hemolytic transfusion reaction and results of monocyte monolayer assays of two of the anti-GIL suggested a potential to cause destruction of transfused GIL+ RBCs.

Geoff Daniels, E. Nicole DeLong, Virginia Hare, Susan T. Johnson, Pierre-Yves LePennec, Delores Mallory, M. Jane Marshall, Cindy Oliver, Peggy Spruell

Immunohematology, Volume 14 , ISSUE 2, 49–52

Article | 04-November-2019


The article presents the results of the investigations of turbocharger shaft bearing using different kinds of lubrication conditions (dry friction and lubrication with different kind of oils). In particular, the wear of the turbocharger shaft surface was evaluated. One of the most frequent failures is the seizure of the turbocharger shaft in the slide bearing, causing its rotation, which leads to destruction of the assembly and costly repairs. On the basis of the conducted tests, it was found

Damian HADRYŚ, Henryk BĄKOWSKI, Zbigniew STANIK, Andrzej KUBIK

Transport Problems, Volume 14 , ISSUE 3, 85–96

Article | 14-December-2020

Indicators of clinically significant red cell antibodies produced by sensitized lymphocytes in liver transplant patients

It has been documented that transplanted livers can carry sensitized lymphocytes that subsequently produce red cell antibodies. We evaluated immunohematological variables in liver donors and recipients for indicators that might be predictive of serological red blood cell (RBC) destruction mediated by the passenger lymphocytes. Organ donor sera with antibody scores greater than ( > ) 60 correlated with a positive direct antiglobulin test (DAT) and need for increased RBC transfusion in liver

BeverIy E.W. Calhoun, M. Pothiawala, G. Musa, B. Baron

Immunohematology, Volume 7 , ISSUE 2, 37–39

Article | 30-November-2020

A comparison of the monocyte J monolayer assay with 51chromium red cell recovery for determining the clinical significance of red cell alloantibodies

with the 51Cr recovery in 11 of 12 subjects. One anti-K1 that caused moderately accelerated red cell destruction (60% recovery at 24 hours) had a negative MMA. Four control subjects with no atypical antibodies had normal autologous RBC 51Cr recoveries and were negative by the MMA technique. The MMA test can be a reliable predictor of in vivo antibody behavior and an acceptable alternative to 51Cr recovery studies.

Richard J. Davey, Susan S. Esty, Jenny F. Chin, Delores Mallory

Immunohematology, Volume 10 , ISSUE 3, 90–94

Review | 14-March-2020

The Cromer blood group system: a review

protein. The RBCs of people with the Cromer null phenotype, Inab, lack DAF but do not appear to demonstrate increased susceptibility to hemolysis. Antibodies to Cromer antigens are rarely encountered, although there is evidence that the antibodies may cause accelerated destruction of transfused RBCs. There is no risk of HDN associated with Cromer system antibodies because the placenta is a rich source of fetally derived DAF, which is thought to adsorb the antibodies.

Jill R. Storry, Marion E. Reid, Mark H. Yazer

Immunohematology, Volume 26 , ISSUE 3, 109–117

Review | 14-October-2020

The Cromer blood group system: a review

DAF protein. The red blood cells (RBCs) of people with the Cromer null phenotype, Inab, lack DAF. Antibodies to Cromer antigens are rarely encountered although there is evidence that the antibodies may cause accelerated destruction of transfused RBCs. There is no risk of hemolytic disease of the newborn associated with Cromer system antibodies because the placenta is a rich source of fetally derived DAF, which is thought to adsorb the antibodies.

Jill R. Storry, Marion E. Reid

Immunohematology, Volume 18 , ISSUE 4, 95–103

Article | 06-December-2020

Clinical correlation of positive direct antiglobulin tests in patients with sickle cell disease

with sickle cell disease and serologic findings of autoimmune hemolytic anemia, but only one had increased RBC destruction attributed to the autoantibody. That patient’s RBCs had IgG and complement on the surface, while those of the other patient had IgG without complement. Functional asplenism may diminish the role of an IgG autoantibody that does not bind complement, since RBCs coated with complement are removed by the liver. Therefore, complement-binding autoantibodies may have particular

Raymond L. Comenzo, Marie E. Malachowski, Eugene M. Berkman

Immunohematology, Volume 8 , ISSUE 1, 13–16

research-article | 18-April-2020

Forest fire detection using wireless sensor networks

Premsai Dasari, Gundam Krishna Jayanth Reddy, Abhishek Gudipalli

International Journal on Smart Sensing and Intelligent Systems, Volume 13 , ISSUE 1, 1–8

research-article | 17-April-2021


brickwork. All the facades were plastered. Other structures of the “Big Block” were of mixed construction as well, which was the main cause of the total destruction of the city block during WWII. The Old Arcade was eclectic in architecture, like most buildings of its period. Both its facades stood out in the row of adjacent buildings as that of a distinct separate structure. All three entrances situated at different levels served as visual markers of the Arcade, immediately distinguishable by virtue of


Architecture, Civil Engineering, Environment, Volume 14 , ISSUE 1, 33–44

Article | 09-November-2020

Measurement of red blood cell-bound C3b and C3d using an enzyme-linked direct antiglobulin test

Complement has a complex role in immune mediated red blood cell (RBC) destruction and usually induces extravascular hemolysis of C3bcoated RBCs by erythrophagocytosis and by acting synergistically with cell-bound immunoglobulins. A sensitive two-stage enzyme-linked direct antiglobulin test (ELDAT) was developed and used to measure RBC-bound C3b and C3d in 120 healthy adult individuals and in 60 patients suffering from a variety of conditions, including warm- and cold-type autoimmune hemolytic

J.D. Bellamy, D.J. Booker, N.T. James, R. Stamps, R.J. Sokol

Immunohematology, Volume 13 , ISSUE 4, 123–131

Case report | 10-January-2018

Central Pontine Myelinolysis

, dysarthria, diplopia and acute para/quadraparesis. Patients can also experience locked in syndrome, where cognitive function is intact but all muscles are paralysed with the exception of eye blinking. CPM gets its name as it occurs when cell dysfunction causes destruction of the myelin sheath of nerve cells in the brain stem, more specifically the pons. It is associated with poor prognosis and prevention is of primary importance. Freddy is a 35 year old freelance graphic designer, fitness

Leigh Arrowsmith, Christopher Tolar

Australasian Journal of Neuroscience, Volume 25 , ISSUE 1, 15–19

Article | 15-April-2020

Update on HDFN: new information on long-standing controversies

Hemolytic disease of the fetus and newborn (HDFN) results from maternal IgG antibodies that cross the placenta to the fetal circulation during gestation and cause RBC destruction and complications before birth (HDF), or anemia and hyperbilirubinemia after birth (HDN), or both. In its most severe form,HDF produces hydrops fetalis,which is characterized by total body edema,hepatosplenomegaly,and heart failure and can lead to intrauterine death. Before discovery of Rh immunoglobulin (RhIG), HDFN

Anne F. Eder

Immunohematology, Volume 22 , ISSUE 4, 188–195

Article | 17-November-2020

Detection of drug-dependent platelet antibodies by use of solid-phase red cell adherence techniques

observed frequency of drug-related immunologic platelet destruction.

Miriam F. Leach, Linda K. Cooper, James P. AuBuchon

Immunohematology, Volume 11 , ISSUE 4, 143–149

Editorial | 31-March-2017

Rheumatoid arthritis: what do MRI and ultrasound show

Rheumatoid arthritis is the most common inflammatory arthritis, affecting approximately 1% of the world’s population. Its pathogenesis has not been completely understood. However, there is evidence that the disease may involve synovial joints, subchondral bone marrow as well as intra- and extraarticular fat tissue, and may lead to progressive joint destruction and disability. Over the last two decades, significant improvement in its prognosis has been achieved owing to new strategies for

Iwona Sudoł-Szopińska, Lennart Jans, James Teh

Journal of Ultrasonography, Volume 17 , ISSUE 68, 5–16

Research paper | 10-October-2018

Effects of extensive amygdaloid lesions on conditioned taste aversion in rats

The role of the amygdala in the acquisition of conditioned taste aversion (CTA) is unclear. The lesion studies that have explored specific nuclei of the amygdala point to a probable involvement of the basolateral amygdala, but it remains unclear whether the function of the amygdala in CTA is limited to the activity of the basolateral amygdala. In the current study, extensive bilateral lesions of the amygdala were performed in Wistar rats to explore if the destruction of the amygdala affects the

Andrés Molero-Chamizo

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 3, 242–250

Original Paper | 10-December-2018

A Novel Approach to Study the Effect of Ciprofloxacin on Biofilms of Corynebacterium spp. Using Confocal Laser Scanning Microscopy

× MIC paradoxically caused an enlargement of areas with live bacteria within the biofilm. Biofilm destruction required the application of ciprofloxacin at a concentration higher than 6 × MIC. This suggests that the use of relatively low doses of antimicrobial agents may increase the number of live bacteria within the biofilm, and further facilitate their detachment from the biofilm’s structure thus leading to the spread of bacteria into the bloodstream or to the neighboring tissues. The method of


Polish Journal of Microbiology, Volume 67 , ISSUE 4, 431–440

original-paper | 27-November-2020

The Effect of Lactobacillus salivarius SGL03 on Clinical and Microbiological Parameters in Periodontal Patients

lead to systemic diseases such as diabetes and cardiovascular diseases (Caton et al. 2018; Dahlen et al. 2019). Therefore, prevention and treatment of periodontitis are crucial not only for the maintenance of teeth and oral health but also for the whole human. Periodontal tissue destruction in the course of inflammation occurs due to both direct bacterial action and activation of indirect immune-inflammatory mechanisms in host tissues (Dahlen et al. 2019). The constant presence of pathogenic


Polish Journal of Microbiology, Volume 69 , ISSUE 4, 441–451

Article | 31-December-2020

Stimulation of Antibody Following 51Chromium Survival Studies

destruction of RBCs during subsequent incompatible transfusions. To study this question, blood samples were collected from six patients with a single atypical alloantibody, seven to nine months after 51Cr RBC survival studies had been performed in an unrelated protocol. Blood had not been transfused in the interim. The samples were tested in parallel with pre-survival samples for change in antibody titer and score. In addition, RBCs used for the 51Cr survival study, sensitized in vitro with pre- and post

Susan S. Esty, Delores Mallory, Richard J. Davey, Tracy Wahl, Julie Zswisza

Immunohematology, Volume 3 , ISSUE 1, 6–8

Report | 06-November-2019

Drug-induced immune neutropenia/ agranulocytosis

Neutrophils are the most abundant white blood cell in blood and play a critical role in preventing infections as part of the innate immune system. Reduction in neutrophils below an absolute count of 500 cells/μL is termed severe neutropenia or agranulocytosis. Drug-induced immune neutropenia (DIIN) occurs when drug-dependent antibodies form against neutrophil membrane glycoproteins and cause neutrophil destruction. Affected patients have fever, chills, and infections; severe infections left

Brian R. Curtis

Immunohematology, Volume 30 , ISSUE 2, 95–101

original-paper | 23-November-2020

Biofilm Production Potential of Salmonella Serovars Isolated from Chickens in North West Province, South Africa


Polish Journal of Microbiology, Volume 69 , ISSUE 4, 427–439

Article | 06-December-2020

Failure to detect a prozoning anti-Fya in the serum of a chronically transfused patient

facility for acute hemorrhage. Only the presence of anti-JH in the serum was documented. To detect possible immune red cell destruction, the patient was monitored by our facility at 24-hour intervals with a direct antiglobulin test and antibody screen. On day 4, a 4+ anti-Fya was identified in the serum and the DAT was negative. Three days later anti-K was also identified. The serologic picture remained unchanged for 10 days, when the DAT became positive. Concurrently, a mixed-field Fya typing (on the

Jody C. Sizemore, Teresa D. Sammons, Jerry N. Clanton

Immunohematology, Volume 8 , ISSUE 2, 44–46

Review Article | 29-December-2017

Chest wall – a structure underestimated in ultrasonography. Part III: Neoplastic lesions

Chest wall neoplasms mainly include malignancies, metastatic in particular. Differential diagnosis should include clinical data; tumor location, extent, delineation; the degree of homogeneity; the presence of calcifications; the nature of bone destruction and the degree of vascularization. The aim of the paper is to present both the benefits and limitations of ultrasound for the diagnosis of chest wall neoplasms. The neoplastic process may be limited to the chest wall; it may spread from the

Andrzej Smereczyński, Katarzyna Kołaczyk, Elżbieta Bernatowicz

Journal of Ultrasonography, Volume 17 , ISSUE 71, 281–288

Research Article | 22-December-2016

Children’s coping styles and trauma symptoms after an explosion disaster

somatization and negative affectivity.Results:The following variables were associated with a higher degree of trauma symptoms for children in grades 6 through 10 and explained 39% to 48% of the unique variance in these symptoms: female gender; the experience of traumatic events pre-disaster; the destruction of property or danger to life occurring during the disaster; the experience of traumatic events post-disaster; and the use of self-blame, emotion regulation, wishful thinking, and cognitive

Mette Elmose, Christina Duch, Ask Elklit

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 4 , ISSUE 3, 132–140

Report | 16-October-2019

Rh and Kell blood group antigen prevalence in a multi-ethnic cohort in Nigeria: implications for local transfusion service

Antigens belonging to the Rh and Kell blood group systems are of major clinical significance because of their immunogenicity and the potential of their consequent antibodies to cause in vivo destruction of exogenous red blood cells (RBCs). Despite the widespread use of transfusion, there are sparse data on the prevalence of Rh and Kell system antigens and their ethnic variability in Nigeria. The objective of this study was to determine the prevalence of the five major Rh (D, C, c, E, e) and

Ademola Samson Adewoyin, Grace Ming Lee, Titilope Adenike Adeyemo, Omolade Augustina Awodu

Immunohematology, Volume 34 , ISSUE 2, 61–65

Case report | 29-June-2016

Charcot arthropathy in ultrasound examination – a case report

autoimmune arthritis, arthritis associated with gout as well as venous thrombosis and injury. The contribution of a local inflammatory reaction and abnormal bone turnover with excessive osteoclast activity might play a role in the etiopathogenesis of this disease. As a result, osseous and articular destruction progresses rapidly leading to irreversible deformity of the foot. Avoiding weight-bearing and resting the foot in a specially selected plaster cast is the most important part of treatment. Patients

Mateusz Płaza, Anna Nowakowska-Płaza, Marta Walentowska-Janowicz, Marek Chojnowski, Iwona Sudoł-Szopińska

Journal of Ultrasonography, Volume 16 , ISSUE 65, 210–215

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