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  • Immunohematology

 

Article | 10-November-2020

Glycophorin A-deficient red cells may have a weak expression of C4-bound Ch and Rg antigens

The blood group antigens Ch and Rg are polymorphisms of C4d. Antigen-positive red blood cells (RBCs) treated with proteases type as Ch-, Rg-. Although RBCs treated with sialidase may type Ch+ Rg+, they cannot be coated with C4 by the 10 percent sucrose method. Since studies of complement binding have shown that glycophorin A (GPA) is an important component for the uptake of C4 by RBCs, we tested all available GPA-deficient RBCs for their Ch and Rg status. Using eluates of human anti-Ch and anti

Patricia Tippett, Jill Storry, Phyllis Walker, Yasuto Okubo, Marion Reid

Immunohematology, Volume 12 , ISSUE 1, 4–7

Article | 26-October-2020

Contribution of MNS to the study of glycophorin A and glycophorin B

Marion E. Reid

Immunohematology, Volume 15 , ISSUE 1, 5–9

Article | 17-November-2020

En(a-)FIN phenotype in a Pakistani

An antibody to a high-incidence antigen in the serum from a Pakistani female (SD) was identified as anti-Ena. Her red cells have the En(a-)FIN phenotype and lack glycophorin A. This is the first En(a-) to be described in a Pakistani individual and represents the fourth family to be reported.

Judy Rapini, Rita Batts, Michelle Yacob, Christine Howard, Prema Singa, Phyllis S. Walker, Marion E. Reid

Immunohematology, Volume 11 , ISSUE 2, 51–53

Article | 01-April-2020

Reduced red blood cell destruction by antibody fragments

Amina Mqadmi, Steven Abramowitz, Xiaoying Zheng, Karina Yazdanbakhsh

Immunohematology, Volume 22 , ISSUE 1, 11–14

Article | 14-October-2020

Low-incidence MNS antigens associated with single amino acid changes and their susceptibility to enzyme treatment

MNS antigens are carried on glycophorin A (GPA), glycophorin B (GPB), or their variants. Antigens at the N-terminus of GPA are sensitive to cleavage by ficin, papain, and trypsin but are resistant to α-chymotrypsin. Antigens at the N-terminus of GPB are sensitive to cleavage by ficin, papain, and α-chymotrypsin but are resistant to trypsin treatment. These characteristics have been used to aid in the identification of blood group alloantibodies. Recent molecular analyses have

Marion E. Reid, Jill Storry

Immunohematology, Volume 17 , ISSUE 3, 76–81

Article | 06-December-2020

En(a-) phenotype in a Japanese blood donor

The first Japanese En(a-) individual (T.N.) was found by screening red cells from 250,000 Japanese blood donors with monoclonal anti-Ena. His serum contained no atypical antibodies and his partial red cell phenotype was M-N-S+s-, although a trypsin-resistant N antigen was detected. His red cells were En(a-) and Wr(b-), as determined by various human and mouse monoclonal antibodies. The absence of glycophorin A (GPA) and the presence of apparently normal glycophorin B (GPB) were demonstrated by

Yasuto Okubo, Taiko Seno, Hideo Yamaguchi, Yoshihisa Miyata, Carole A. Green, Geoffrey L. Daniels

Immunohematology, Volume 9 , ISSUE 4, 105–108

Article | 16-February-2021

Clinical approach after identification of a rare anti-Ena in a prenatal sample

Introduction The MNS blood group system (ISBT 002) consists of red blood cell (RBC) antigens located on glycophorin A (GPA) and glycophorin B (GPB). The GYPA and GYPB genes encoding these glycophorins are located on the long arm of chromosome 4.1,2 The most frequently encountered antibodies to antigens in this system by a transfusion medicine service are those directed against M, N, S, and s. In rare cases, individuals may lack GPA or both GPA and GPB on their RBCs because of gene deletion, and

P.J. Howard, L. Guerra, D.K. Kuttner, M.R. George

Immunohematology, Volume 35 , ISSUE 4, 159–161

Review | 15-April-2020

Review: molecular basis of MNS blood group variants

The MNS blood group antigens are expressed in the RBC membrane on glycophorin A (GPA), glycophorin B (GPB), or combinations of both. GPA expresses the M or N antigen,whereas GPB expresses the S or s antigen and the N antigen (′N′). Both glycophorin genes (GYPA and GYPB) are located on the long arm of chromosome 4 and share 95 percent sequence identity. This high degree of sequence identity, together with the rare involvement of a third homologous gene (GYPE), provides an increased

P. Palacajornsuk

Immunohematology, Volume 22 , ISSUE 4, 171–182

Case report | 01-December-2019

Hemolytic disease of the fetus and newborn owing to anti-U, successfully treated with repeated intrauterine transfusions

Hemolytic disease of the fetus and newborn (HDFN) owing to anti-U has rarely been reported. U is part of the MNS system. M and N glycoproteins are located on glycophorin A (GPA); S and s antigens are on glycophorin B (GPB). Individuals who lack GPB are S– and s– and also lack U. The U– phenotype occurs almost exclusively in the African population and has a very low frequency (0.25%). Anti-U is of immunoglobulin G class and can cause hemolytic transfusion reaction and HDFN. In

Johanna Strindberg, Joachim Lundahl, Gunilla Ajne

Immunohematology, Volume 29 , ISSUE 2, 51–54

Review | 20-March-2020

MNS blood group system: a review

The MNS blood group system is second only to the Rh blood group system in its complexity. Many alloantibodies to antigens in the MNS system are not generally clinically significant although antibodies to low-prevalence and high-prevalence MNS antigens have caused hemolytic disease of the fetus and newborn. The MNS antigens are carried on glycophorin A (GPA), glycophorin B (GPB), or hybrids thereof, which arise from single-nucleotide substitution, unequal crossing over, or gene conversion

Marion E. Reid

Immunohematology, Volume 25 , ISSUE 3, 95–101

Article | 06-December-2020

Anti-Uz found in mother's serum and child's eluate

A saline-reactive antibody, anti-Uz, that reacted stronger with S+ than with S- red blood cells (RBCs) and failed to react with U- or ficin-treated RBCs has been previously reported. We describe an antibody of similar specificity in the postpartum serum of an untransfused woman and the eluate from her fourth child's cord RBCs. The mother's RBCs typed S-s+U+, He+(weak), and appeared to have normal glycophorin A and B content, as determined by immunoblotting. The direct antiglobulin test

Sandra M. Read, Mary M. Taylor, Marion E. Reid, Mark A. Popovsky

Immunohematology, Volume 9 , ISSUE 2, 47–49

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