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Article | 14-October-2020

Anti-Mta associated with three cases of hemolytic disease of the newborn

The Mta antigen is a low-frequency red blood cell (RBC) surface antigen and is an established antigen of the MNSs blood group system. There has been one report of anti-Mta –induced hemolytic disease of the newborn (HDN) in the literature to date. We describe a family in which three children were affected by neonatal anemia. The clinical and hematologic findings were consistent with HDN, despite repeatedly negative direct antiglobulin tests (DAT) on cord RBCs. Serologic investigations

Carol C. Cheung, Daniel Challis, George Fisher, Susan J. Russell, Andrew Davis, Hayley Bruce, Julie Watt, Beng H. Chong

Immunohematology, Volume 18 , ISSUE 2, 37–39

Article | 18-October-2020

Moderate hemolytic disease of the newborn due to anti-Hr0 in a mother with the D––/D–– phenotype

Hemolytic disease of the newborn (HDN) due to anti-Hr0 antibody is typically severe and often fatal. We report a case of moderate HDN due to anti-Hr0 in a woman with the D––/D–– phenotype. A 33-yearold woman delivered her second child who was mildly jaundiced. The highest level of bilirubin was 26.1 mg/dL on the third day postpartum and the hemoglobin concentration was 14.0 g/dL. The newborn recovered after phototherapy and no mental retardation was noticed after 1 year

Barbara Żupańska, B. Lenkiewicz

Immunohematology, Volume 16 , ISSUE 3, 109–111

Article | 09-November-2020

Anti-Jk3 with no clinical evidence of HDN

A sample was submitted to a reference lab from a 27-year-old Asian female, gravida 4 para 1, for antibody identification. Anti-Jk3 with an IgM component was identified. Subsequently, the antibody was eluted from the infant’s cord and venous red blood cells. Normal bilirubin and hematocrit levels ruled out hemolytic disease of the newborn (HDN). Anti-Jk3 has been implicated in two cases of mild HDN. In this case, this noncomplement-binding antibody caused a positive direct Coombs test

Celeste J. Hunter, Michael D. Ziebol

Immunohematology, Volume 13 , ISSUE 4, 136–137

Article | 14-October-2020

Likelihood of D heterozygosity in Mestizo Mexicans and Mexican Americans

Information on the gene frequencies of the Rh system in the Mexican or Mexican American population is currently not available in the medical literature, thus hindering management of pregnancies at risk for development of hemolytic disease of the newborn. Data from four recent large studies in the broader scientific literature of Mestizo Mexicans and Mexican Americans is reviewed. Gene frequencies are calculated from the pooled data. A table of gene frequencies in the Caucasian and African

Norman D. Means, Nicholas Bandarenko, Kenneth J. Moise, Jr., Mark E. Brecher

Immunohematology, Volume 17 , ISSUE 1, 22–23

Article | 18-October-2020

A successful delivery of a baby from a D––/ D–– mother with strong anti-Hr0

We describe the first reported case in Korea of a woman with a D––/ D–– phenotype, a high-titer anti-Hr0, and the successful delivery of her newborn. The mother had a history of spontaneous abortion and artificial termination. In her third pregnancy, a live infant was delivered, but died of severe hemolytic disease of the newborn due to anti-Hr0 in spite of intensive medical intervention. In her fourth pregnancy, at 22 weeks gestation, the titer of anti-Hr0 was 1024

Dong Hee Whang, Hee Chung Kim, Mina Hur, Jung Hwan Choi, Joong Shin Park, Kyou Sup Han

Immunohematology, Volume 16 , ISSUE 3, 112–114

Case report | 14-October-2020

Moderate hemolytic disease of the newborn (HDN) due to anti-Rh17 produced by a black female with an e variant phenotype

Marla C. Brumit, Gary E. Carnahan, James R. Stubbs, Jill R. Storry, Marion E. Reid

Immunohematology, Volume 18 , ISSUE 2, 40–42

Case report | 09-November-2020

A case of hemolytic disease of the newborn due to anti-Kpa

A patient with hemolytic disease of the newborn (HDN) due to maternal anti-Kpa alloimmunization is described. Although there are few reports in the literature, it appears that HDN due to anti-Kpa is often mild and transfusion therapy is rarely required. However, in this case, the baby’s hemoglobin progressively decreased and on day 18 a blood transfusion was administered, but jaundice was not severe enough for exchange transfusion.

Laura Costamagna, Mario Barbarini, Gianluca Viarengo, Ambrogio Pagani, Paola Isernia, Laura Salvaneschi

Immunohematology, Volume 13 , ISSUE 2, 61–62

Article | 14-December-2020

Microcomputer software simulating problems in Rh immune globulin prophylaxis and hemolytic disease of the newborn

Our purpose was to develop educational software that would simulate laboratory investigation of problems in Rh immune globulin prophylaxis and hemolytic disease of the newborn. An interactive, branching style program was developed using a 256K Penonal Computer (International Business Machines, Boca Raton, FL). The software has been used in over 125 institutions for preprofessional and continuing professional education.

Patrick K. Hardman, Jill T. Hardman, PeggyJ. Brown, Deborah A. Borek, Malcolm L. Beck

Immunohematology, Volume 7 , ISSUE 1, 12–15

Article | 31-December-2020

An Example of Mild Hemolytic Disease of the Newborn Caused by Anti-Cob

A woman whose serum contained multiple alloantibodies delivered a full-term infant with mild hemolytic disease of the newborn. The direct antiglobulin test performed on the cord cells was positive with monospecific anti-IgG. An acid elution performed on the cord cells yielded anti-Cob. These findings were consistent with the presence of anti-Cob in the maternal serum. Neonatal clinical findings showed a mildly affected infant who demonstrated a moderate rise in total bilirubin and slight

Nancy B. Steffey, Mary A. Lieb

Immunohematology, Volume 3 , ISSUE 1, 9–10

Case report | 30-November-2020

Case report: IgG1 Rh antibodies causing moderate hemolytic disease of the newborn

was group A, D positive, E negative, with a 3+ direct antiglobulin test. The eluate revealed anti-D and -hrB. Treatment of the hemolytic disease of the newborn included phototherapy, intravenous fluids, and transfusion of 60 mL of mother's deglycerolized red blood cells.

C. Faye Kugele, Cindy K. Oliver, Maria A. Carney, Jayne Hollander

Immunohematology, Volume 10 , ISSUE 4, 124–126

Article | 18-October-2020

Significant ABO hemolytic disease of the newborn in a group B infant with a group A2 mother

ABO hemolytic disease of the newborn (HDN) occurs almost exclusively in infants of blood group A or B who are born to group O mothers because IgG anti-A or -B occurs more commonly in group O than in group A or B individuals. We report a case in which clinically significant ABO-HDN occurred in a group B neonate from anti-B of a group A2 mother. The IgG anti-B titer was much higher (256) than that found in a group A1 mother/infant control group (≤ 32). The maternal antibody screen was negative

Hye-Ran Jeon, Beverly E.W. Calhoun, Mohammad Pothiawala, Marguerite Herschel, Beverly W. Baron

Immunohematology, Volume 16 , ISSUE 3, 105–108

Article | 14-December-2020

Determining the significance of anti-K1 in hemolytic disease of the newborn (HDN)

Anti-K1 is capable of causing severe hemolytic disease of the newborn (HDN), but few cases are seen due to the low frequency of the antigen. A total of 1,215 pregnancies from 1962 to 1989 were reviewed. There were 404 non-anti-D clinically significant antibodies, of which 103 (25%) were anti-K1. Anti-K1 was detected in nine of the women at delivery, of whom two had antigen-positive infants who were clinically unaffected. Antigen typing was done on 64 of the 85 fathers. Forty-seven were K: - 1

Patricia L. Strohm, Janice F. Blazina, Richard W. O'Shaughnessy, Melanie S. Kennedy, Jane M. Moore

Immunohematology, Volume 7 , ISSUE 2, 40–42

Article | 10-November-2020

Do monocyte ADCC assays accurately predict the severity of hemolytic disease of the newborn caused by antibodies to high-frequency antigens?

Monocyte ADCC assays are helpful indicators of the severity of hemolytic disease of the newborn (HDN) due to anti-D. It would be particularly useful if the assays also accurately predicted the ability of antibodies to high-frequency antigens (HFA) to cause HDN. To investigate this possibility, 14 antenatal sera containing antibodies to HFA were tested and the results correlated with the severity of HDN. Antibody titers were determined using an indirect antiglobulin test (IAT). Eight sera 

Stephen F. Garner, Alan Devenish

Immunohematology, Volume 12 , ISSUE 1, 20–26

Review | 06-December-2020

Review: hemolytic disease of the newborn

Judith Martin

Immunohematology, Volume 9 , ISSUE 4, 96–100

Article | 15-April-2020

Serologic and molecular genetic management of a pregnancy complicated by anti-Rh18

Richard L. Haspel, Dawn Michelle, Richard M. Kaufman, Sunitha Vege, Connie M. Westhoff

Immunohematology, Volume 22 , ISSUE 3, 132–135

Article | 09-November-2020

Comparison of hemagglutination and solid phase titration methods for determination of critical prenatal antibody titers

Brenda C. Alder, Stephanie H. Summers, Virginia Hare

Immunohematology, Volume 13 , ISSUE 3, 84–89

Case report | 15-April-2020

Case report:moderate hemolytic disease of the newborn due to anti-G

Aaron R. Huber, George T. Leonard, Rita W. Driggers, Sakhone B. Learn, Colleen W. Gilstad

Immunohematology, Volume 22 , ISSUE 4, 166–170

Article | 14-October-2020

Screening for RBC antibodies - what should we expect from antibody detection RBCs

George Garratty

Immunohematology, Volume 18 , ISSUE 3, 71–77

Case report | 01-December-2019

Possible suppression of fetal erythropoiesis by the Kell blood group antibody anti-Kpa

Michelle Tuson, Kim Hue-Roye, Karen Koval, Sherwin Imlay, Rajendra Desai, Gayatri Garg, Esam Kazem, Diane Stockman, Janis S. Hamilton, Marion E. Reid

Immunohematology, Volume 27 , ISSUE 2, 58–60

Article | 01-April-2020

Management of pregnancy complicated by anti-hrB/anti-HrB

Nay Win, Malcolm Needs, Louise Tillyer

Immunohematology, Volume 23 , ISSUE 4, 143–145

Review | 14-March-2020

Laboratory methods for Rh immunoprophylaxis: a review

S. Gerald Sandler, Srividya Sathiyamoorthy

Immunohematology, Volume 26 , ISSUE 3, 92–103

Report | 01-December-2019

Implications of the Kidd blood group system in renal transplantation

The association of the Kidd blood group system with hemolytic transfusion reactions and hemolytic disease of the newborn is well known. The Kidd antigens, which are localized to the HUT/UT-B urea transport protein, are found on red blood cells and the endothelial cells of the blood vessels of the medulla of the kidney. Recently it has been suggested that these antigens might play a role as minor histocompatibility antigens in renal transplantation. In the current case, the appearance of an anti

Angela Rourk, Jerry E. Squires

Immunohematology, Volume 28 , ISSUE 3, 91–94

Review | 06-December-2020

Review: the LW blood group system

The LW blood group system had its origin in the early Rh experiments of the 1940s and played an important role in our understanding of hemolytic disease of the newborn. Considered for a number of years to be the animal equivalent of the human Rh(D) antigen, LWa has been shown to be unique. Biochemical studies have located the antigen on a different protrein from proteins of the Rh antigens; however, the interdependence of LW and D still exists. The disappearance of LW antigens in various

Jill Storry

Immunohematology, Volume 8 , ISSUE 4, 87–93

Article | 17-February-2021

K antigens on neonatal red blood cells blocked by anti-K with titer of 32

J. Novoselac, M. Raos, G. Tomac, M. Lukić, B. Golubić Ćepulić

Immunohematology, Volume 36 , ISSUE 2, 54–57

Case report | 17-November-2020

Case report: anti-Cra in pregnancy

A 39-year-oId Grenadian multiparous patient presented in the 12th week ofpregnancy. Her red cells were found to have the rare Cr(a-) (ISBT Number 202001) phenotype within the Cromer complex, and her serum contained anti-Cra. To date, anti-Cra has not been implicated in hemolytic disease of the newborn (HDN), but there are very few published reports on this topic. This case provided an excellent opportunity for study. The patient’s serum showed no detectable functional activity in in vitro

Anne C. Dickson, Claire Guest, Mary Jordon, Jackie Banks, Belinda Kumpel

Immunohematology, Volume 11 , ISSUE 1, 14–17

Article | 09-November-2020

A maternal warm-reactive autoantibody presenting as a positive direct antiglobulin test in a neonate

Autoimmune hemolytic anemia in pregnancy is a rare cause of hemolytic disease of the newborn. This report describes a neonate with a mild hemolytic process and a positive direct antiglobulin test (DAT) presenting as the first manifestations of a maternal warm-reactive autoantibody. A full-term male neonate, blood group O, had a strongly positive DAT and laboratory evidence suggestive of a mild hemolytic process. The neonate’s mother was also group O and had a negative antibody screen

Terry D. Williamson, Linda H. Liles, Douglas P. Blackall

Immunohematology, Volume 13 , ISSUE 1, 6–8

Review | 14-October-2020

The Cromer blood group system: a review

DAF protein. The red blood cells (RBCs) of people with the Cromer null phenotype, Inab, lack DAF. Antibodies to Cromer antigens are rarely encountered although there is evidence that the antibodies may cause accelerated destruction of transfused RBCs. There is no risk of hemolytic disease of the newborn associated with Cromer system antibodies because the placenta is a rich source of fetally derived DAF, which is thought to adsorb the antibodies.

Jill R. Storry, Marion E. Reid

Immunohematology, Volume 18 , ISSUE 4, 95–103

Article | 10-November-2020

Anti-Holley detected in a primary immune response

. The antibody was reactive at room temperature, 37°C, and in the antiglobulin phase. IgG and IgM components of anti-Hy were demonstrated in the maternal serum, documenting a primary immune response. This resulted in serologic findings not previously described for anti-Hy. A direct antiglobulin test on the newborn red cells was negative and there was no clinical evidence of hemolytic disease of the newborn (HDN). A monocyte monolayer assay performed with maternal serum yielded negative results

Vicki J. Barrett, M. Margaret O’Brien, John J Moulds, Peggy Spruell, Valerie Jackson, James R. Stubbs

Immunohematology, Volume 12 , ISSUE 2, 62–65

Article | 14-October-2020

Rapid genotyping of the major alleles at the Duffy (FY) blood group locus using real-time fluorescence polymerase chain reaction

The Duffy blood group system has clinical importance due to involvement in transfusion reactions and hemolytic disease of the newborn. Recently, the molecular basis of the two alleles, FY*A and FY*B (125G>A), and the mutation situated in the promoter region of the FY gene (–33T>C), have been elucidated. In order to develop an accurate, easy, and rapid genotyping method, we describe a procedure using the LightCycler®. Samples from 53 Caucasian Portuguese blood donors and 7 black

Fernando M. Araújo, Christina Pereira, Ana Aleixo, Isabel Henriques, Fátima Monteiro, Elsa Meireles, Pedro Lacerda, Luis M. Cunha-Ribeiro

Immunohematology, Volume 17 , ISSUE 2, 42–44

Article | 14-October-2020

Acute hemolytic transfusion reaction caused by anti-Coa

Coa is a high-frequency blood group antigen in the Colton blood group system expressed on red blood cells (RBCs) of approximately 99.8 percent of random persons. Anti-Coa has been reported to cause delayed hemolytic transfusion reactions, hemolytic disease of the newborn, and accelerated clearance of RBCs in vivo. Acute hemolytic transfusion reactions (AHTRs) have not previously been reported. A 58-year-old man was hospitalized for vascular surgery. Initial blood bank evaluation revealed anti

Randal B. Covin, Karen S. Evans, Richard Olshock, Hannis W. Thompson

Immunohematology, Volume 17 , ISSUE 2, 45–49

Article | 06-December-2020

Anti-Uz found in mother's serum and child's eluate

these RBCs had the same reactivity as the maternal serum. The child showed no clinical signs of hemolytic disease of the newborn. In contrast to previous reports, these results suggest an immune form of anti-Uz.

Sandra M. Read, Mary M. Taylor, Marion E. Reid, Mark A. Popovsky

Immunohematology, Volume 9 , ISSUE 2, 47–49

Report | 01-December-2019

Seroprevalence of unexpected red blood cell antibodies among pregnant women in Uganda

evidence of agglutination. Nine of the 21 samples demonstrated the presence of clinically significant RBC antibodies with anti-S being the most common, 8 samples demonstrated the presence of benign or naturally occurring antibodies, and 4 had only inconclusive reactivity. This study revealed a relatively high frequency of D and a low frequency of demonstrable clinically significant alloantibodies that may cause hemolytic disease of the newborn or hemolytic transfusion reactions among pregnant women in

Kristina Eipl, Clemensia Nakabiito, Kabali Bwogi, Mahnaz Motevalli, Angela Roots, Lorraine Blagg, J. Brooks Jackson

Immunohematology, Volume 28 , ISSUE 4, 115–117

Article | 22-November-2020

An improved method for removal of red cell-bound immunoglobulin using chloroquine solution

In some patients with autoimmune hemolytic anemia or hemolytic disease of the newborn, the red cells are so heavily coated with immunoglobulin that phenotyping cannot be carried out unless the antibody is removed without destroying the red cell antigens. Studies were performed initially to determine the optimum conditions for removal of immunoglobulin from red blood cells (RBCs) using chloroquine. Group O, R1r RBCs were coated with serial dilutions of anti-D; aliquots were incubated in

Angela E. Beaumont, R. Stamps, D.J. Booker, R.J. Sokol

Immunohematology, Volume 10 , ISSUE 1, 22–24

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