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original-paper | 03-September-2019

Purification, Characterization and Inhibition of Alanine Racemase from a Pathogenic Strain of Streptococcus iniae

for the antimicrobial drugs development (Wang et al. 2017). Numerous inhibitors were identified as able to affect the activity of alanine racemase (Kim et al. 2003a; Kim et al. 2003b). Many of these inhibitors were structural analogs of alanine; they interact with the enzyme-bound PLP, covalently bound to some eukaryotic PLP-dependent enzymes and lead to cellular toxicity (Toney 2005). PLP-related off-target effects could be overcome by using enzyme inhibitors that are not substrate analogs

MURTALA MUHAMMAD, YANGYANG LI, SIYU GONG, YANMIN SHI, JIANSONG JU, BAOHUA ZHAO, DONG LIU

Polish Journal of Microbiology, Volume 68 , ISSUE 3, 331–341

Case report | 09-October-2019

Development of red blood cell autoantibodies following treatment with checkpoint inhibitors: a new class of anti-neoplastic, immunotherapeutic agents associated with immune dysregulation

Ipilimumab, nivolumab, and pembrolizumab represent a new class of immunotherapeutic drugs for treating patients with advanced cancer. Known as checkpoint inhibitors, these drugs act to upregulate the cellular and humoral immune response to tumor antigens by inhibiting T-cell autoregulation. As a consequence, they can be associated with immune-related adverse events (irAEs) due to loss of self-tolerance, including rare cases of immune-related cytopenias. We performed a retrospective clinical

Laura L.W. Cooling, John Sherbeck, Jonathon C. Mowers, Sheri L. Hugan

Immunohematology, Volume 33 , ISSUE 1, 15–21

research-article | 08-March-2021

Shear wave elastography detects novel imaging biomarkers of aromatase inhibitor–induced joint pain: a pilot study

Introduction Aromatase inhibitors (AIs) have become first-line standard adjuvant endocrine therapy for postmenopausal women with hormone receptor positive (HR+) breast cancer. Although outcomes have improved compared to tamoxifen(1), AI therapy has been associated with significant, activity-limiting musculoskeletal symptoms including arthralgia, myalgia, and joint stiffness, collectively called AI-associated arthralgias (AIA)(2,3). Among the most commonly reported side effects experienced by

Jessica A. Martinez, Mihra S. Taljanovic, Russell S. Witte, Andres A. Nuncio Zuniga, Betsy C. Wertheim, C. Kent Kwoh, Brian A. Goldstein, Denise J. Roe, Pavani Chalasani

Journal of Ultrasonography, Volume 21 , ISSUE 84, 1–6

original-paper | 31-August-2021

Rapid Detection and Differentiation of KPC and MBL Carbapenemases among Enterobacterales Isolates by a Modified Combined-Disk Test

Company, USA) plates inoculated with bacterial suspensions of 2.80 ± 0.15 McFarland optical density. The inhibition zones were measured after incubation for 6 hours at 35 ± 2°C in ambient air. An increase of ≥ 5 mm in the inhibition zone diameter of the imipenem (or meropenem) disk containing inhibitors (APB, EDTA, or both) in comparison to the same disk without the corresponding inhibitor was suggestive of KPC, MBL, or both carbapenemases production, respectively. Quality control strains included

MING WEI, PENG WANG, SHUAI WANG, CHUNXIA YANG, LI GU

Polish Journal of Microbiology, Volume 70 , ISSUE 3, 387–394

Original Paper | 27-September-2017

Bioconversion of 16-dehydropregnenolone Acetate to Exclusively 4-androstene-3,17-dione by Delftia acidovorans MTCC 3363

Delftia acidovorans MTCC 3363 was found to convert 16-dehydropregnenolone acetate (16-DPA) exclusively to 4-androstene-3, 17-dione (AD). Addition of 9α-hydroxylase inhibitors was not required for preventing the accumulation of byproducts. The effect of pH, tempera­ture, substrate concentration, surfactants and carrier solvents on this bioconversion has been studied. 16-DPA was maximally converted in buffered medium at pH 7.0, at temperature 30°C and 0.5 mg ml–1 substrate

Pushpendra Awadhiya, Tushar Banerjee, Shridhar Patil

Polish Journal of Microbiology, Volume 66 , ISSUE 3, 321–326

Original Paper | 04-December-2017

Temperature, pH and Trimethoprim-Sulfamethoxazole Are Potent Inhibitors of Biofilm Formation by Stenotrophomonas maltophilia Clinical Isolates

Marjan Biočanin, Haowa Madi, Zorica Vasiljević, Milan Kojić, Branko Jovčić, Jelena Lozo

Polish Journal of Microbiology, Volume 66 , ISSUE 4, 433–438

Review Paper | 13-October-2014

Recent advances in pathophysiology studies and treatment of epilepsy in neurocutaneous disorders

most prominent and recent (up to 2014 year) publications on the treatment and mechanisms of epilepsy in selected neurocutaneous disorders. We aimed to emphasize evidence-based medicine recommendations as well as basic experimental studies dealing with molecular mechanisms of epileptogenesis. Discussion and conclusions. Recent advances in disease-modifying treatment options such as mTOR inhibitors in patients with tuberous sclerosis complex open up new perspectives for neurologists. Traditional

Krzysztof Sadowski, Sergiusz Jóźwiak

Journal of Epileptology, Volume 22 , ISSUE 2, 99–108

Original Paper | 04-December-2017

Identification of Lactobacillus delbrueckii and Streptococcus thermophilus Strains Present in Artisanal Raw Cow Milk Cheese Using Real-time PCR and Classic Plate Count Methods

way and that genomic DNA solutions were free of PCR inhibitors. These methods revealed the presence of L. delbrueckii and S. thermophilus. The real-time PCR enabled quantification with a detection of 101–103 CFU/g of product. qPCR-standard curves were linear over seven log units down to 101 copies per reaction; efficiencies ranged from 77.9% to 93.6%. Cheese samples were analysed with plate count method and qPCR in parallel. Compared with the classic plate count method, the newly developed

Milena A. Stachelska

Polish Journal of Microbiology, Volume 66 , ISSUE 4, 491–499

Research paper | 14-August-2017

Effectors of large-conductance calcium-activated potassium channel modulate glutamate excitotoxicity
in organotypic hippocampal slice cultures

neuroprotective effects of BKCa channel modulators. Using organotypic hippocampal slice cultures exposed to glutamate, we demonstrated that preincubation of the slices with the BKCa channel opener NS1619 resulted in decreased neuronal cell death measured as reduced uptake of propidium iodide. This neuroprotective effect was reversed by preincubation with the BKCa channel inhibitors paxilline and Iberiotoxin (IbTx). Moreover, mitochondrial respiration measurements revealed that NS1619 induced an

Marta Piwońska, Adam Szewczyk, Ulrich H. Schröder, Klaus G. Reymann, Piotr Bednarczyk

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 1, 20–31

Research paper | 25-July-2017

Inhibition of neuronal and inducible nitric oxide synthase does not affect the analgesic effects of NMDA antagonists in visceral inflammatory pain

Previously we described the antinociceptive effect of magnesium sulfate and dizocilpine (MK-801) in the visceral and somatic rat models of pain. In the somatic model of pain, we established the influence of selective inhibitors of neuronal and inducible nitric oxide synthase on the antihyperalgesic effects of magnesium sulfate and dizocilpine. Therefore, the objective of the present study was to determine in the rat model of visceral pain whether same mechanisms are involved in the

Dragana Srebro, Sonja Vučković, Milica Prostran

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 2, 110–116

research-article | 08-July-2020

The inhibitory effects of bile acids on catalytic and non-catalytic functions of acetylcholinesterase as a therapeutic target in Alzheimer’s disease

therapeutic adjuvants for patients that are suffering from AD or other related cognitive disorders. This study additionally provides new structural information for the rational design of new inhibitors against AChE.

Leila Sadeghi, Reza Yekta, Gholamreza Dehghan

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 2, 108–116

Article | 30-November-2018

POSSIBILITIES OF PREVENTION AND TREATMENT OF HUMAN CYTOMEGALOVIRUS INFECTIONS INCLUDING NEW DRUGS AND COMPOUNDS WITH POTENTIAL APPLICATION

caused by the Hepatitis B virus (HBV) and Hepatitis C virus (HCV), have been developed and registered [22, 23]. Much attention is also devoted to the viral infections among patients with immunosuppression. Currently, intravenous ganciclovir (GCV) and oral L-valyl ester of ganciclovir-valganciclovir (VGCV) are considered in the control of hCMV infections. Alternatively, in the case of resistance to these inhibitors or the occurrence of unacceptable side effects, the second and third choice drugs are

Anna Majewska, Beata Młynarczyk-Bonikowska, Magdalena Malejczyk, Sławomir Majewski, Grażyna Młynarczyk

Postępy Mikrobiologii - Advancements of Microbiology, Volume 58 , ISSUE 3, 291–299

Review | 28-April-2020

Review: complement receptor 1 therapeutics for prevention of immune hemolysis

Karina Yazdanbakhsh

Immunohematology, Volume 21 , ISSUE 3, 109–118

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