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Short Communication | 30-March-2017

Antiviral Resistance of Splenocytes in Aged Mice

We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin in splenocytes infected with Encephalomyocarditis virus (EMCV). Recombinant mouse lactoferrin (rmLF) and bovine lactoferrin (bLF) were used. There were no differences in the susceptibility to EMCV infection in the studied age categories. Both types of lactoferrins were protective in young and old mice. The study confirmed the undisturbed

Ewa Zaczyńska, Jolanta Artym, Maja Kocięba, Timo Burster, Marian Kruzel, Maria Paprocka, Michał Zimecki

Polish Journal of Microbiology, Volume 66 , ISSUE 1, 131–134

Research paper | 04-August-2017

High-dose 1,25-dihydroxyvitamin D supplementation elongates the lifespan of Huntington’s disease transgenic mice

a transgenic mouse model of Huntington’s disease. Methods: Our study was performed on N171-82Q Huntington’s disease transgenic mice in age- and gender-matched groups. We collected data on the motor state and survival of the mice. Results: The results demonstrate that though vitamin D3 had no effect on the motor performance of transgenic mice, but significantly increased the lifespan of transgenic animals (Kaplan-Meier survival curves: vehicle-supplemented group

Máté` Fort Molnár, Rita Török, Evelin Sümegi, László Vécsei, Péter Klivényi, Levente Szalárdy1

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 3, 176–181

original-paper | 31-May-2021

The Effect of Lactobacillus plantarum BW2013 on The Gut Microbiota in Mice Analyzed by 16S rRNA Amplicon Sequencing

ZX633 may ameliorate the infant diarrhea microbiota, thus reducing the rate of infant bacterial diarrhea (Wang et al. 2020b). After treated with mixed lactic acid bacteria, Staphylococcus aureus infection could be prevented in mice, and the structure of intestinal microbiota could be improved (Ren et al. 2018). Lactic acid bacteria and Bifidobacteria are the most commonly used probiotics (He et al. 2020b). Lactobacillus plantarum, a rod-shaped, facultative anaerobic, Gram-positive lactic acid


Polish Journal of Microbiology, Volume 70 , ISSUE 2, 235–243

Research Article | 03-September-2018

Morphological Re-Description and 18 S rDNA Sequence Confirmation of the Pinworm Aspiculuris tetraptera (Nematoda, Heteroxynematidae) Infecting the Laboratory Mice Mus musculus

Aspiculuris tetraptera is a heteroxynematid nematoda infecting most of the laboratory animals, occasionally mice which represent the mostly used animal for biological, medical, and pharmacological studies. The present study aimed to investigate the prevalence of nematode parasites infection in the laboratory mice Mus musculus in Egypt. Morphologically, this oxyurid possessed four distinct cephalic papillae on a cephalic plate, with three small rudimental lips carrying two sessile poorly

Rewaida Abdel-Gaber, Fathy Abdel-Ghaffar, Saleh Al Quraishy, Kareem Morsy, Rehab Saleh, Heinz Mehlhorn

Journal of Nematology, Volume 50 , ISSUE 2, 117–132

original-paper | 04-June-2020

Lactobacillus fermentum JX306 Restrain D-galactose-induced Oxidative Stress of Mice through its Antioxidant Activity

risk of intestinal infection in patients (Mikelsaar and Zilmer 2009). L. fermentum Suo could eliminate the chain reaction of oxygen free radicals and lipid peroxidation as well as inhibit HCl/ethanol-induced oxidative damage in the gastric tissue (Suo et al. 2016). L. fermentum MTCC589 could improve antioxidant enzyme activity, resist the reinfection of Escherichia coli, and reduce the immune aging of mice (Sharma et al. 2014). In this study, 481 of LAB strains from Chinese traditional fermented


Polish Journal of Microbiology, Volume 69 , ISSUE 2, 205–215

research-article | 30-November-2019

Physical activity and environmental enrichment: Behavioural effects of exposure to different housing conditions in mice

memories (Fares et al., 2013). However, a prior experiment with male National Medical Research Institute (NMRI) mice did not confirm the beneficial effects of exposure to MCs on anxiety-like response and habituation to novel environments (Mesa-Gresa et al., 2014). In that study, the authors observed that mice reared in these environments showed an increase in exploratory behaviour in the hole board (HB) test, as well as, an increase in motor activity in the EPM. More recently, Kentrop et al. (2018

Raisa Rabadán, Marta Ramos-Campos, Rosa Redolat, Patricia Mesa-Gresa

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 4, 374–385

Original Paper | 15-January-2018

Adenosine receptor agonists differentially affect the anticonvulsant action of carbamazepine and valproate against maximal electroshock test-induced seizures in mice

-NECA and A 1 (preferentially) and A2 – 2-chloroadenosine. Their possible anticonvulsant effects were studied in a threshold electroconvulsive test for maximal electroconvulsions. The protective activity of AEDs alone or in combinations with adenosine agonists was evaluated in the form of their respective ED50 values necessary to protect 50% of mice against tonic extension of the hind limbs, following maximal electroshock, delivered through ear electrodes. The specificity of interactions

Mirosław Jasiński, Magdalena Chrościńska-Krawczyk, Stanisław J. Czuczwar

Journal of Epileptology, Volume 25 , ISSUE 1-2, 21–29

Research paper | 01-August-2017

Effects of social stress and clomipramine on emotional memory in mice

We have previously observed impairing effects of social defeat stress (CSDS) on inhibitory avoidance (IA) in mice. Given the similarity between changes produced by social stress in animals and symptoms of certain human psychopathologies such as depression and anxiety, the effects of the antidepressant clomipramine on IA impairment produced by CSDS were evaluated in the present study. Male CD1 mice were randomly assigned to the groups: non-stressed+saline, non-stressed+clomipramine, stressed

Aranzazu Duque, Concepción Vinader-Caerols, Santiago Monleón

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 3, 225–233

original-paper | 28-June-2019

Gastric Microbiota Alteration in Klebsiella pneumoniae-Caused Liver Abscesses Mice

. Atarashi et al. (2017) hold that oral Klebsiella spp. colonizing the intestines causes inflammatory bowel disease (IBD). It has also been identified that oral inoculation of K. pneumoniae K1 or K2 serotype isolates causes liver abscess infections in mice (Tu et al. 2009; Chen et al. 2014). Gastric microbiota provides a biological barrier against the invasion of foreign pathogens entering the oral pathway, playing a vital role in maintaining gastrointestinal health. (Bik et al. 2006). For example


Polish Journal of Microbiology, Volume 68 , ISSUE 2, 247–254

research-article | 15-October-2020

Phenylbutyrate administration reduces changes in the cerebellar Purkinje cells population in PDC-deficient mice

et al., 2016; Apps et al., 2018). The cerebellar compartmentation is determined mainly by intrinsic differences between subsets of PCs as well as the pattern of afferent and efferent connections (Leto et al., 2016). Specification of the PC subtype probably occurs when PCs undergo terminal mitosis between E10 and E13 (Miale and Sidman, 1961; Leto et al., 2016) and start migrating to their destinations in the cerebellum of mice (Yuasa et al., 1991; Komuro, 2013). Development studies have shown two

Ilona Klejbor, Saleh Mahmood, Natalia Melka, Adriana Ebertowska, Janusz Morys, Ewa K. Stachowiak, Michal K. Stachowiak, Mulchand S. Patel

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 305–321

Research paper | 06-February-2018

Marble burying as compulsive behaviors in male and female mice

Marble burying is considered an, albeit controversial, animal model of the compulsive like behaviors of obsessive-compulsive disorder (OCD). Hallmark features of OCD patients are similarities and, more prominent, differences from anxiety disorders, e.g., the absence of sex differences and resistance to spontaneous remission. We report an experiment on marble burying by male and female C57/BL6/N mice. Animals were administered either the classic anxiolytic drug, diazepam, that targets the GABA

George T. Taylor, Sandra Lerch, Sabine Chourbaji

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 3, 254–260

Original Paper | 22-December-2016

Additive interactions between retigabine and oxcarbazepine in the chimney test and the model of generalized tonic-clonic seizures in mice

performance) in adult male albino Swiss mice. Methods. Isobolographic analysis (type I) was applied to characterize interactions for the combination of RTG with OXC with respect to its anticonvulsant and acute side (neurotoxic) effects, as determined in the MES and chimney tests, respectively. Results. The combination of RTG with OXC at the fixed-ratios of 1:3, 1:1 and 3:1 produced additive interactions in the MES test in mice. Similarly, the combination of RTG with OXC at the fixed-ratio of 1:1 produced

Mirosław Zagaja, Barbara Miziak, Katarzyna Załuska, Paweł Marzęda, Bartłomiej Drop, Karolina Załuska-Patel, Grażyna Ossowska, Stanisław J. Czuczwar, Jarogniew J. Łuszczki

Journal of Epileptology, Volume 24 , ISSUE 2, 87–94

research-article | 30-November-2019

The modulatory role of β-amyloid in the regulation of nociception in mice

-expressing CRND8 transgenic mice (Shukla et al., 2013), suggesting that β-amyloid may be responsible for blunted pain perception observed in Alzheimer’s patients. Recent studies have shown that the extracellular signal-regulated kinase P44/42 (ERK1/2) and cyclic AMP response element-binding protein (CREB) are involved in various types of pain transmission. Both CREB and ERK protein expression are elevated in dorsal root ganglia (DRG) and spinal cord in rat neuropathic pain models (Crown et al., 2006; Ji

Jing Hui Feng, Hee Jung Lee, Su Min Sim, Madhuri Shende, Hong Won Suh

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 4, 358–363

Article | 01-April-2020

Reduced red blood cell destruction by antibody fragments

period of the RBCs in the circulation. Direct injection of mouse RBC-specific Ter-119 monoclonal antibody into mice resulted in a more severe anemia compared with that in mice injected with the Ter-119 F(ab´)2 fragment. We found that mouse RBCs coated in vitro with the Ter-119 F(ab´)2 fragment, when transfused into mice,survived longer in circulation compared with RBCs coated with whole Ter-119 IgG molecule. The data support the conclusion that antibodies can be rendered less pathogenic

Amina Mqadmi, Steven Abramowitz, Xiaoying Zheng, Karina Yazdanbakhsh

Immunohematology, Volume 22 , ISSUE 1, 11–14

Review | 25-July-2017

Behavioral verification of associative learning in whisker-related fear conditioning in mice

Fear-conditioning is one of the most widely used paradigms in attempts to unravel the processes and mechanisms underlying learning and plasticity. In most Pavlovian conditioning paradigms an auditory stimulus is used as the conditioned stimulus (CS), but conditioning to a tactile CS can also be accomplished. The whisker-to-barrel tactile system in mice offers a convenient way to investigate the brain pathways and mechanisms of learning and plasticity of the cerebral cortex. To support the claim

Anita Cybulska-Kłosowicz

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 2, 87–97

Research paper | 04-May-2018

Antimuscarinic-induced convulsions in fasted mice after food intake: no evidence of spontaneous seizures, behavioral changes or neuronal damage

Prolonged or repeated seizures have been shown to cause spontaneous recurrent seizures, increased anxiety-related behavior, locomotor hyperactivity, impaired functions of learning and memory, and neuronal damage in the hippocampus and other brain regions in animals. Mice and rats treated with antimuscarinic drugs after fasting for two days or less develop convulsions after being allowed to eat ad libitum. To address whether such behavioral and neuroanatomic changes occur following these

Nurhan Enginar, Asiye Nurten, Aslı Zengin Türkmen, Gül İpek Gündoğan, Zeynep Güneş Özünal

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 4, 373–381

research-article | 30-November-2019

Protective effects against memory impairment induced by methylglyoxal in mice co-treated with FPS-ZM1, an advanced glycation end products receptor antagonist

(Yamagishi et al., 2008; Deane et al., 2012; Cai et al., 2016; Hong et al., 2016). Moreover, memory deficits induced by the treatment with HMGB1 were prevented in RAGE knockout mice (Mazarati et al., 2011). FPS-ZM1 is a high-affinity RAGE antagonist, permeable to the blood-brain barrier that binds to the V domain of RAGE. In rodents, FPS-ZM1 was able to inhibit RAGE-mediated influx of circulating Aβ40 and Aβ42 into the brain (Deane et al., 2012). In addition, FPS-ZM1 inhibited β-secretase activity, thus

Jozimar Carlos Szczepanik, Abel Freitas Garcia, Gudrian Ricardo Lopes de Almeida, Mauricio Peña Cunha, Alcir Luiz Dafre

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 4, 364–374

research-article | 06-April-2020

Local field potential power spectra and locomotor activity following treatment with pseudoephedrine in mice

, 1981). In contrast, morphine causes somnolence-like depressive activity (Wiffen et al., 2014) but also exhibits locomotor activity, as an excitatory effect (Babbini and Davis, 1972), indicating that morphine activates relatively direct CNS mechanisms, rather than enhancing cortical hyperexcitability or alertness, to increase locomotor activity. Moreover, morphine is an opioid that affects the electrical activities of the nucleus accumbens and striatum and increases movement in mice (Reakkamnuan et

Nusaib Sa-ih, Chayaporn Reakkamnuan, Nifareeda Samerphob, Dania Cheaha, Saree Niyomdecha, Ekkasit Kumarnsit

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 1, 19–31

research-article | 07-July-2020

Anandamide in the anterior hypothalamus diminishes defensive responses elicited in mice threatened by Epicrates cenchria constrictor serpents

more physiological situation as recently demonstrated in another ethological approaches using a moving “robo-beetle” as a threat (Heinz et al., 2017). However, a previous study showed that mice decreased their defensive responses during confrontation with snakes after anandamide microinjection into the substantia nigra pars reticulata (Almada et al., 2015). Another ethological study showed that administration of anandamide into the dPAG diminished the duration of defensive immobility displayed by

Tayllon dos Anjos-Garcia, Norberto Cysne Coimbra

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 2, 179–191

Research paper | 15-January-2019

Acute cold allodynia induced by oxaliplatin is attenuated by amitriptyline

assessed the cold reactivity threshold of albino Swiss mice treated with oxaliplatin. We also investigated if amitriptyline, a tricyclic antidepressant drug and a sodium channel inhibitor, could attenuate cold allodynia caused by this chemotherapeutic drug. Cold allodynia was induced using a single intraperitoneal dose of oxaliplatin. In the cold plate test while testing various temperatures the pain sensitivity threshold was assessed at different time-points after oxaliplatin (late-phase allodynia

Anna Furgała, Robert Sałat, Kinga Sałat

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 4, 315–321

Short Communication | 10-October-2018

MMP-3 deficiency does not influence the length and number of CA1 dendrites of hippocampus of adult mice

hippocampal region, we decided to investigate whether genetic deletion of MMP-3 affects neuronal morphology in this area. To this end, we used Golgi staining to compare dendritic morphology of pyramidal neurons in the CA1 region in MMP-3-deficient and wild-type mice. Surprisingly, in contrast to the results obtained in cortex, extensive analysis of dendritic morphology in the CA1 region revealed no significant differences between MMP-3 knockout and wild-type groups. These results suggest that the impact

Daria Nowak, Lies De Groef, Lieve Moons, Jerzy W. Mozrzymas

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 3, 281–286

Research paper | 06-October-2017

Cerebellar cortex development in the weaver condition presents regional and age-dependent abnormalities without differences in Purkinje cells neurogenesis

Ataxias are neurological disorders associated with the degeneration of Purkinje cells (PCs). Homozygous weaver mice (wv/wv) have been proposed as a model for hereditary cerebellar ataxia because they present motor abnormalities and PC loss. To ascertain the physiopathology of the weaver condition, the development of the cerebellar cortex lobes was examined at postnatal day (P): P8, P20 and P90. Three approaches were used: 1) quantitative determination of several cerebellar

Joaquín Martí, María C. Santa-Cruz, José P. Hervás, Shirley A. Bayer, Sandra Villegas

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 1, 53–65

Research paper | 06-February-2018

Potential role of dopamine transporter in behavioral flexibility

cognitive processes. Here we used a gene knockout mouse model to investigate the role of DAT in the performance on the Attentional Set-Shifting Task (ASST) stages dependent upon the OFC and the DMS. Additionally, behavior of mice after repeated administration of selective DAT inhibitor, GBR 12909, was examined. The animals were treated with the inhibitor to elicit a compensatory DAT up-regulation following withdrawal. Learning was slower and the number of errors during reversal learning and intra

Anita Cybulska-Klosowicz, Julia Dabrowska, Sebastian Niedzielec, Renata Zakrzewska, Aleksandra Rozycka

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 2, 176–189

original-paper | 05-December-2019

Inhibition of Drug Resistance of Staphylococcus aureus by Efflux Pump Inhibitor and Autolysis Inducer to Strengthen the Antibacterial Activity of β-lactam Drugs

Materials and Methods Ethics statement. The BALB/c mice were housed in micro-isolator cages and received food and water freely. The laboratory temperature was 24 ± 1°C, and relative humidity was 40–80%. All animal studies were conducted according to the experimental practices and standards approved by the Animal Welfare and Research Ethics Committee at Jilin University (no: IZ-2009-008). The protocols were reviewed and approved by the committee. All animal studies were performed under isoflurane


Polish Journal of Microbiology, Volume 68 , ISSUE 4, 477–491

review-article | 30-November-2020

Neurobiological effects of forced swim exercise on the rodent hippocampus: a systematic review

<0.05? Methodological quality assessment questions modified from (Ainge et al., 2011) and (Downs and Black, 1998). After search in the selected databases 56 papers met the inclusion criteria therefore included in this review. From the 56 studies listed, 87.5% works used rats and 12.5% used mice, in which 80% of them utilized male and 20% female. The average body weight for rats were 180-400 g and for mice 30-40 g with the adult life stage the most used in exercise. Groups of rodents submitted

Rodrigo Freire Oliveira, Karina Maia Paiva, Gabriel Sousa da Rocha, Marco Aurélio de Moura Freire, Dayane Pessoa de Araújo, Lucídio Cleberson de Oliveira, Fausto Pierdoná Guzen, Paulo Leonardo Araújo de Gois Morais, José Rodolfo Lopes de Paiva Cavalcanti

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 1, 58–68

research-paper | 14-June-2019

Selective neuronal death following exposure to methylenedioxypyrovalerone is accompanied by an inhibition of NMDA receptor NR2B subunit expression

INTRODUCTION Synthetic cathinones belong to the group of the so-called novel psychoactive substances (NPS) also known as ‘designer drugs’. One member of the family, methylenedioxypyrovalerone (MDPV), is a frequently used psychoactive drug of abuse. In a previous study (Ádám et al., 2014), we found a marked increase in the number of apoptotic cells in the piriform cortex, retrosplenial area, hippocampus CA1 and nucleus accumbens (NAc), without an overall change of cell density, in 7-day-old mice

László István Gerecsei, Tamás Balázsa, Diego Echevarría, Ágota Ádám, Gergely Zachar, András Csillag

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 1, 92–100

research-article | 30-November-2019

A smaller olfactory bulb in a mouse model of Down syndrome

place: this has been suggested to underlie hypocellularity of the OB, ultimately leading to deficit in olfactory learning through a reduction in the number of new granule neurons migrating to the OB from the subventricular zone. This has been challenged by others (López-Hidalgo et al., 2016). Similar alterations have also been observed in persons with DS. Moreover, Ts65Dn mice present impaired refinement of synaptic connections by olfactory neurons in the OB (William et al., 2017). Accordingly

Pietro Bontempi, Barbara Cisterna, Manuela Malatesta, Elena Nicolato, Carla Mucignat-Caretta, Carlo Zancanaro

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 4, 375–380

Research paper | 04-May-2018

Antiallodynic effect of intrathecal resiniferatoxin on neuropathic pain model of chronic constriction injury

neuropathic pain or epidurally and topically to produce prolonged analgesic effects. However, the use of RTX is controversial because its neurotoxicity and margin of safety have not been addressed adequately. The present study evaluates the effect of intrathecal RTX on the induction and allodynia behavior of animals submitted to neuropathic pain by chronic constriction injury (CCI). Methods: 160 Swiss mice were randomly distributed into two groups: intrathecal pre-treatment group (PRE) aiming the effect

Julia Risso Parisi, Ana Laura Martins de Andrade, Josie Resende Torres Silva, Marcelo Lourenço Silva

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 4, 317–322

research-article | 30-June-2021

Anodal tDCS applied to the left frontal cortex abrogates scopolamine-induced fear memory deficit via the dopaminergic system

in the frontal cortex. Besides, we found that tDCS over the left frontal cortex of mice modulates fear memory dysfunction induced by β1-adrenoceptor blocker propranolol (Nasehi et al., 2017a) or lithium (Hamdami et al., 2020). It has been shown that cognitive processes and symptomatology of diseases involving dopamine are sensitive to the application of tDCS over the dorsolateral prefrontal cortex. It has been suggested that subcortical effects of frontal tDCS reach to the subcortical areas such

Shahsanam Abbasi, Mohammad Nasehi, Mohaddeseh Ebrahimi-Ghiri, Mohammad-Reza Zarrindast

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 2, 172–180

research-paper | 12-August-2019

The effect of bupropion augmentation of minocycline in the treatment of depression

is inhibited by bupropion. Due to its dual action, it is considered a drug of interest in the treatment of depression (Stahl et al., 2004). Bupropion showed antidepressant effects at 10 mg/kg in mice (Kale and Addepalli, 2014). Minocycline showed anti-depressant activity in different preclinical and preliminary clinical studies. Minocycline is known for its neuroprotective properties by directly promoting neurogenesis, being a broad spectrum tetracycline antibiotic (Soczynska et al., 2012). It

Monica Bendale, Sharon Ronald D'souza, Veeranjaneyulu Addepalli, Pravin Popatrao Kale

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 2, 217–224

Research paper | 01-August-2017

The false-positive responses of analgesic drugs to the intradermal serotonin- and compound 48/80-induced scratches as an animal model of itch

animal model of itch differentiates itch or pain to show efficacy of clinically effective analgesic drugs as a back translation. In this study, we explored the effects of different group of analgesic drugs on serotonin and compound 48/80-induced scratching behavior in Balb-C mice. Serotonin (25 μg) and compound 48/80 (100 μg) was injected intradermally in a volume of 50 μl into the rostral part of skin on the back of male mice and scratches were counted for a 30-min observation period. Morphine (1, 3

Fatih Ilkaya, Ozgur Yesilyurt, Melik Seyrek, Ozgur Gunduz, Tayfun Ide, Ahmet Akar, Ahmet Ulugol, Hasan Guzel, Ahmet Dogrul, Durmus Ucar, Caner Gunaydin

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 3, 234–243

research-article | 30-November-2020

Bluetooth 5.2 Technology and Application

Jian Wang, Hui Liang

International Journal of Advanced Network, Monitoring and Controls, Volume 6 , ISSUE 2, 32–36

Research paper | 25-July-2017

Pharmacokinetics and pharmacodynamics of a novel Acetylcholinesterase Inhibitor, DMNG-3

had a positive effect of improvement of learning and memory in mice in passive avoidance tests. The elimination half-life (T1/2) was 14.07±1.29, 15.87±1.03 h, and the total clearance (CL) values were 0.70±0.11, 0.78±0.13 L/h/kg, respectively. The pharmacokinetic studies showed that DMNG-3 has a slowly clearance and large distribution volume in experimental animals, and its disposition is linear over the range of doses tested. The liver, small intestine, stomach, and large intestine were the major

Xin-Guo Zhang, Fei Kou, Guo-Di MA, Peng Tang, Zhong-Duo Yang

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 2, 117–124

original-paper | 27-March-2019

In Vitro and In Vivo Activity of Zabofloxacin and Other Fluoroquinolones Against MRSA Isolates from A University Hospital in Egypt

zabofloxacin has not been yet introduced. In addition, the in vivo protective activity of zabofloxacin and comparator fluoroquinolones against systemic infection caused by MRSA clinical isolate was evaluated using a mice model. Experimental Materials and Methods Test organisms and bacterial identification. One hundred-sixteen clinical isolates of MRSA were collected from the routine laboratory of Alexandria Main University Hospital (AMUH) over a six-month period between January 2017 to July 2017. The


Polish Journal of Microbiology, Volume 68 , ISSUE 1, 59–69

original-paper | 04-June-2020

N-acetylcysteine (NAC) Attenuating Apoptosis and Autophagy in RAW264.7 Cells in Response to Incubation with Mycolic Acid from Bovine Mycobacterium tuberculosis Complex

and cell damage of host cells after incubation with MA. Animal experiments were performed to investigate the role of NAC in antagonizing the effects of MA in the induction of apoptosis and autophagy. Experimental Materials and Methods Animals. Male ICR (Institute of Cancer Research) mice aged six weeks were purchased from the Chinese Academy of Sciences (Shanghai, China). The Ethics Committee approved all experimental procedures for Laboratory Animals at the Ningxia University. Mice were kept


Polish Journal of Microbiology, Volume 69 , ISSUE 2, 223–229

Review | 28-April-2020

Review: complement receptor 1 therapeutics for prevention of immune hemolysis

anemia (AIHA). Complement receptor 1 (CR1) is a large single-pass glycoprotein that is expressed on a variety of cell types in blood, including RBCs and immune cells. Among its multiple functions is its ability to inhibit complement activation. Furthermore, gene knockout studies in mice implicate a role for CR1 (along with the alternatively spliced gene product CR2) in prevention of autoimmunity. This review discusses the possibility that the CR1 protein may be manipulated to prevent and treat AIHA

Karina Yazdanbakhsh

Immunohematology, Volume 21 , ISSUE 3, 109–118

Report | 20-March-2020

Characterization of three novel monoclonal anti-Oka

Anti-Oka was first described by Morel and Hamilton in 1979. The Oka antigen has a very high incidence, and only eight probands that are Ok(a–) have been found; all are of Japanese heritage. In this study, we describe the generation and characterization of three novel monoclonal antibodies (Mabs), MIMA-25, MIMA-144, and MIMA-149. The reactivity of these three Mabs was compared with the original human polyclonal anti-Oka. Mice were immunized with transfected HEK cells to induce an immune

Mary H. Tian, Gregory R. Halverson

Immunohematology, Volume 25 , ISSUE 4, 174–178

Research paper | 31-July-2017

Age‑dependent concomitant changes in synaptic function and GABAergic pathway in the APP/PS1 mouse model

of the disruption documented in the glutamate system. To build on previous research in this field, experiments were designed to determine if previously documented synaptic dysfunction in AD models is concomitantly observed with excitation/inhibition imbalance as suggested by observation of seizure and seizure‑like pathology in such models. We report changes in synaptic function in aged APPPS1 mice not observable in the younger cohort. These changes in synaptic function are furthermore accompanied

Tutu Oyelami, An De Bondt, Ilse Van den Wyngaert, Kirsten Van Hoorde, Luc Hoskens, Hamdy Shaban, John A. Kemp, Wilhelmus H. Drinkenburg

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 4, 282–293

Research paper | 06-February-2018

Nucleus accumbens local field potential power spectrums, phase-amplitude couplings and coherences following morphine treatment

In the past decade, neural processing has been extensively studied in cognitive neuroscience. However, neural signaling in the nucleus accumbens (NAc) that might clarify reward process remained to be investigated. Male Swiss albino ICR mice implanted with intracranial electrodes into the NAc and the ventral tegmental area (VTA) were used for morphine administration and local field potential (LFP) recording. One-way ANOVA revealed significant increases in low (30.3–44.9 Hz) and high (60.5–95.7

Chayaporn Reakkamnuan, Dania Cheaha, Ekkasit Kumarnsit

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 3, 214–224

research-paper | 14-June-2019

Protective effects of M8-B, a TRPM8 antagonist, on febrile- and pentylenetetrazol-induced seizures

-, and ligand-gated ion channel (Voets et al., 2007). Menthol is a TRPM8 agonist with well-known cooling attribute. Intravenous administration of this substance makes animals prefer warmer places, indicating its important role in the modulation of temperature. Previous studies have shown that TRPM8 knock-out (KO) mice exhibit a disturbed perception of coldness (Bautista et al., 2007) with an absence of normal avoidance response to harmful coldness (Dhaka et al., 2007). Activation of TRPM8 increases

Nazanin Zandi, Nosaibeh Riahi Zaniani, Ali Moghimi, Ali Roohbakhsh

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 1, 86–91

Report | 01-December-2019

The production, serologic evaluation, and epitope mapping of ten murine monoclonal Dombrock antibodies

The Dombrock (Do) glycoprotein is a glycosylphosphatidylinositol (GPI)-linked membrane protein carrying Dombrock blood group antigens. There are no standardized typing reagents for Doa or Dob. We have developed ten different monoclonal antibodies (MoAbs) that are specific for Dombrock. The objectives of this study were to characterize these MoAbs serologically and determine the epitopes they recognize. MoAbs were generated by standard fusion methods. Mice were immunized with transfected human

Magdalena Grodecka, Kazimiera Wasniowska, Gregory Halverson, Karina Yazdanbakhsh, Marion E. Reid, Elwira Lisowska

Immunohematology, Volume 28 , ISSUE 4, 124–129

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