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Short Communication | 26-August-2016

Pexophagy in Penicillin G Secretion by Penicillium chrysogenum PQ-96

Penicillin G oversecretion by Penicillium chrysogenum PQ-96 is associated with a strictly adjusted cellular organization of the mature and senescent mycelial cells. Abundant vacuolar phagy and extended cellular vacuolization combined with vacuolar budding resulting in the formation of vacuolar vesicles that fuse with the cell membrane are the most important characteristic features of those cells. We suggest as follows: if the peroxisomes are integrated into vacuoles, the penicillin G formed in

Wiesław Kurzątkowski, Anita Gębska-Kuczerowska

Polish Journal of Microbiology, Volume 65 , ISSUE 3, 365–368

Short Communication | 15-March-2016

Antimicrobial Activity of Penicillin G and N-acetylcystein on Planktonic and Sessile Cells of Streptococcus suis

The aim of this study was to investigate the capacity of Streptococcus suis strains to form biofilms and to evaluate the antimicrobial activity of Penicillin G and N-acetylcystein (NAC) on both S. suis sessile and planktonic forms. Only non-typeable isolates of S. suis were correlated with a greater biofilm formation capacity. The MCI of Penicillin G and NAC required for inhibiting biofilm growth were higher than the required concentration for inhibiting planktonic growth. The combinations of

Ivette Espinosa, Michel Báez, Evelyn Lobo, Siomara Martínez, Marcelo Gottschalk

Polish Journal of Microbiology, Volume 65 , ISSUE 1, 105–109

Research paper | 29-September-2017

Interaction between urethane and cannabinoid CB1 receptor agonist and antagonist in penicillin-induced epileptiform activity

Previous experimental studies have shown that various anesthetics alter the effects of cannabinoid agonists and antagonists on the cardiac response to different stimuli. Since no data have shown an interaction between urethane and cannabinoid signaling in epilepsy, we examined the suitability of urethane with regard to testing the effects of a cannabinoid CB1 receptor agonist and an antagonist on penicillin-induced epileptiform activity in rats. Permanent screw electrodes for

Gokhan Arslan, Sabiha Kubra Alici, Mustafa Ayyildiz, Erdal Agar

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 2, 128–136

Article | 10-June-2019


1. Introduction The discovery and industrial production of penicillin G by high-yielding Penicillium chrysogenum strains was a great success which allowed to open the era of antibiotic therapy. Penicillin G has saved millions of human beings from annihilation. The β-lactams are some of the oldest and most widely used antibiotics in human society. In industrial strains penicillin G is secreted in amounts of 45–50 g per liter of the fermentation broth. The biosynthesis and secretion of such

Wiesław Kurzątkowski, Paulina Górska, Małgorzata Główka, Katarzyna Woźnica, Aleksandra Zasada

Postępy Mikrobiologii - Advancements of Microbiology, Volume 58 , ISSUE 1, 80–85

Research paper | 06-February-2018

Effects of Cornus mas L. and Morus rubra L. extracts on penicillin-induced epileptiform activity: an electrophysiological and biochemical study#

Traditionally, Morus rubra L. (Moraceae) (red mulberry) and Cornus mas L. (Cornacea) (cornelian cherry) fruits are eaten fresh and are also used in marmalades, juices, jam, natural dyes in Turkey and are believed to have beneficial effects in case of multiple health issues such as antipyretic, diarrhea and intestinal parasites. However, the effects of M. rubra and C. mas on epilepsy has not been known. This study evaluates the effects of M. rubra and C. mas extracts on penicillin-induced

Filiz Tubaş, Sedat Per, Abdulkadir Taşdemir, Ayşe Kaçar Bayram, Mehmet Yıldırım, Aydın Uzun, Recep Saraymen, Hakan Gümüş, Ferhan Elmalı, Hüseyin Per

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 1, 45–56

Short Communication | 28-June-2017

Erythromycin or Clindamycin – is it Still an Empirical Therapy against Streptococcus agalactiae in Patients Allergic to Penicillin?

Retrospective analysis of Streptococcus agalactiae antibiotic susceptibility isolated in 2010–2013 was performed. Penicillin was still the first-line antibiotic. Due to the high percentage of strains resistant to erythromycin and clindamycin empirical treatment with these antibiotics may not be effective. Lower resistance rate to erythromycin and clindamycin among strains isolated from infected pregnant women and newborns were observed than among strains isolated from samples from

Piotr Leszczyński, Beata Sokół-Leszczyńska, Bronisława Pietrzak, Anna Sawicka-Grzelak, Mirosław Wielgoś

Polish Journal of Microbiology, Volume 66 , ISSUE 2, 265–268

research-paper | 12-August-2019

The effects of moderate running exercise and L-tyrosine on penicillin-induced epileptiform activity in rats

INTRODUCTION Experimental research using animal models plays an important role in the investigation of the pathogenesis of epilepsy, where epileptic seizures are stimulated in the models. One frequently used experimental epilepsy model is induced by penicillin (Erfanparast and Tamaddonfard 2015; Zhu et al., 2018; Tokiwa et al., 2018). Penicillin administration causes acute and focal epileptic activity similar to the epileptic activity associated with an imbalance between inhibitory and

Yildirim Kayacan, Emin Can Kisa, Babak Elmi Ghojebeigloo, Suleyman Emre Kocacan, Mustafa Ayyildiz, Erdal Agar

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 2, 148–154

Article | 14-October-2020

Practical aspects of investigating drug-induced immune hemolytic anemia due to cefotetan or ceftriaxone - a case study approach

In the 1970s, the most common causes of drug-induced immune hemolytic anemia were methyldopa and penicillin. Since 1990, the most common causes of drug-induced immune hemolytic anemia have been the second- and third-generation cephalosporins, cefotetan and ceftriaxone. Three case histories illustrate the common findings in the serologic investigation of immune hemolytic anemias due to these two drugs.

Patricia A. Arndt

Immunohematology, Volume 18 , ISSUE 2, 27–32

original-paper | 03-September-2019

Characteristics of Listeria monocytogenes Strains Isolated from Milk and Humans and the Possibility of Milk-Borne Strains Transmission

disks with penicillin (1 U), ampicillin (2 μg), merope-nem (10 μg), erythromycin (15 μg) and cotrimoxazole (1.25–23.75 μg) (Becton Dickinson, United States) were used. Incubation of antibiograms was conducted in the atmosphere enriched in 5% CO2 at 35°C for 18 h. The results were interpreted according to the recommendations of EUCAST v. 8.0. Evaluation of the biofilm formation ability of L. monocytogenes strains. Quantitative evaluation of biofilm formation by L. monocytogenes strains was performed


Polish Journal of Microbiology, Volume 68 , ISSUE 3, 353–369

Original Paper | 27-September-2017

MRSA in Pig Population

4–4.5 (31.9%) old pigs. The 98.7% of 74 further investigated MRSA isolates were resistant to penicillin, 94.9% to tetracycline, 45.6% to cephalexin and 10 different spa types were found among which spa type t011 was the most widespread. To the best of our knowledge, this is the first time MRSA was researched in sow milk and the first description of the presence of MRSA in several age groups of pigs in Latvia.

Meldra Ivbule, EdvĪns Miklaševičs, Liene Čupāne, Laima Bērziņa, Andris Bāliņš, Anda Valdovska

Polish Journal of Microbiology, Volume 66 , ISSUE 3, 383–392

Original Paper | 15-March-2016

Streptococcus anginosus (milleri) Group Strains Isolated in Poland (1996–2012) and their Antibiotic Resistance Patterns

PFGE and MLVF analyses. All analyzed strains are sensitive to penicillin, a substantial group of strains is resistant to macrolides and the majority of strains are resistant to tetracycline.

Katarzyna Obszańska, Izabella Kern-Zdanowicz, Aleksandra Kozińska, Katarzyna Machura, Elżbieta Stefaniuk, Waleria Hryniewicz, Izabela Sitkiewicz

Polish Journal of Microbiology, Volume 65 , ISSUE 1, 33–41

original-paper | 28-March-2019

Predominance of Lactobacillus plantarum Strains in Peruvian Amazonian Fruits

using commercial paper discs (Oxoid) with the antimicrobial compound, as described in Bauer et al. (1966). According to the criteria of the European Food Safety Authority (EFSA, 2012) the antimicrobials selected were as follows: amoxicillin (10 µg), ampicillin (10 µg), bacitracin (10 µg), clindamycin (2 U), chloramphenicol (30 µg), erythromycin (15 µg), kanamycin (30 µg), gentamicin (10 µg), novobiocin (30 µg), penicillin (10 µg), rifampicin (30 µg), streptomycin (10 µg), sulfamethoxazole


Polish Journal of Microbiology, Volume 68 , ISSUE 1, 127–137

Article | 06-December-2020

Serologic investigation of fatal hemolytic anemia associated with a multiple drug history and Rh-like autoantibody

A patient who expired during an episode of gross intravascular hemolysis had a complex medical history, including renal disease, Coombs positive anemia of unclear etiology, recent transfusion, and cholecystectomy. Drug history included 21 different medications, including penicillin, acetaminophen, procainamide, furosemide, sulindac, and tolmetin, all of which have been associated with a positive direct antiglobulin test or drug-induced hemolytic anemia. The patient had a history of recent use

Nancy I. Maddox, Debra Futral, Floyd T. Boudreau

Immunohematology, Volume 8 , ISSUE 3, 70–76

Report | 06-November-2019

How we investigate drug-induced immune hemolytic anemia

Regina M. Leger, Patricia A. Arndt, George Garratty

Immunohematology, Volume 30 , ISSUE 2, 85–94

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