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research-article | 30-November-2019

Crocin acts as a neuroprotective mediator against methylphenidate-induced neurobehavioral and neurochemical sequelae: Possible role of the CREB-BDNF signaling pathway

from stress-induced damage via an up-regulation of CREB and BDNF; however, this hypothesis has not been confirmed. Therefore, the aim of this study was to evaluate the potential neuroprotective role of crocin against MPH-induced hippocampal impairment, and assess the potential mediating role of the P-CREB-BDNF signaling pathway in this process. METHODS Animals Seventy adult Wistar male rats, weighing between 250-300 g, were purchased from the lab house of the Iran University of Medical Sciences

Andia Ebrahimzadeh, Sara Yousefi Moghadam, Hanieh Rahimi, Majid Motaghinejad, Manijeh Motevalian, Sepideh Safari, Mobina Abbasi Mesrabadi

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 4, 352–366

Research paper | 10-October-2018

Hindlimb suspension-induced cell apoptosis in the posterior parietal cortex and lateral geniculate nucleus: corresponding changes in c-Fos protein and the PI3K/Akt signaling pathway

microgravity environment for 0 (Control group), 7, 14, or 28 days. We found a significant increase in cellular apoptosis in the PPC and the LGN after 7 days of simulated microgravity. In addition, there was an increase in expression of c-Fos protein in the PPC, and a repression of the PI3K/Akt signaling pathway in the LGN after 7 days. Based on these results, we conclude that short-term simulated microgravity may induce cell apoptosis in the PPC and LGN, and reflect a neural adaptive process to accommodate

Wei Huang, Chen Chen, Xufeng Liu

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 3, 220–230

research-article | 15-October-2020

RhoA/Rock2/Limk1/cofilin1 pathway is involved in attenuation of neuronal dendritic spine loss by paeonol in the frontal cortex of D-galactose and aluminum-induced Alzheimer’s disease-like rat model

Nrf2-ARE pathway via up-regulating sirt1 (Zhang et al., 2018), attenuate the inflammatory responses of endothelial cells via stimulating monocytes-derived exosomal microRNA-22 (Liu et al., 2018), and ameliorate glucose and lipid metabolism in experimental diabetes by activating Akt (Xu et al., 2019). In addition, paeonol has an anti-atherosclerotic effect against vascular smooth muscle cell proliferation by up-regulation of autophagy via the AMPK-mTOR signaling pathway (Wu et al., 2017), prevents

Fei Han, Hui Xu, Jun-Xian Shen, Chuan Pan, Zong-Hao Yu, Jing-Jing Chen, Xiu-Ling Zhu, Ya-Fei Cai, Ya-Ping Lu

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 225–244

Research Article | 22-May-2019


Katarzyna Jas, Urszula Małolepsza

Postępy Mikrobiologii - Advancements of Microbiology, Volume 56 , ISSUE 3, 275–281

Review | 10-October-2018

Charcot-Marie-Tooth type 1A drug therapies: role of adenylyl cyclase activity and G-protein coupled receptors in disease pathomechanism

Artur J. Kiepura, Andrzej Kochański

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 3, 198–209

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