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Article | 20-April-2020

An unusual anti-H lectin inhibited by milk from individuals with the Bombay phenotype

;A1B; the extract failed to react with the RBCs from 25 individuals with the Bombay (Oh) phenotype and was inhibited by H secretor saliva, hence it was characterized as anti-H. However, its inhibition by milk samples from five mothers with the Bombay phenotype called into question its specificity as anti-H. The lectin reacted as strongly with group O ii (adult) RBCs as with normal OI RBCs,ruling out its specificity as anti-HI. Hemagglutination inhibition was observed with 2'fucosyllactose (Type

Sanmukh R. Joshi, K. Vasantha, Janine S. Robb

Immunohematology, Volume 21 , ISSUE 1, 1–4

Article | 01-April-2020

H-deficient Bombay and paraBombay red blood cells are most strongly agglutinated by the galactophilic lectins of Aplysia and Pseudomonas aeruginosa that detect I and P1 antigens

The galactophilic lectins Aplysia gonad lectin (AGL) and Pseudomonas aeruginosa lectin (PA-IL),which detect human I and P1 RBC antigens, were examined for hemagglutination of H+ (group O and B) and H-deficient (Bombay and para-Bombay phenotype) RBCs. The results were compared with those obtained using two other galactophilic lectins, Maclura pomifera lectin (MPL) and Arachis hypogaea (peanut) agglutinin (PNA), which share T-antigen affinity, and two fucose-binding H-specific lectins, Ulex

Nechama Gilboa-Garber, Dvora Sudakevitz, Cyril Levene, Naomi Rahimi-Levene, Vered Yahalom

Immunohematology, Volume 22 , ISSUE 1, 15–22

Article | 15-February-2021

An update on the H blood group system

New FUT1 Null Alleles Causing the Bombay Phenotype Since publication of the original review article in 2016,1 11 new alleles silencing the FUT1 gene were published for H– individuals from different populations (Table 1). The new alleles FUT1*01N.22–*01N.25 were formally assigned by the International Society of Blood Transfusion working party. Zanjani et al.2 describe the first homozygous loss of almost the entire FUT1 gene region by a large deletion. Five alleles represented point mutations

E.A. Scharberg, C. Olsen, P. Bugert

Immunohematology, Volume 35 , ISSUE 2, 67–68

Review | 09-October-2019

The H blood group system

The H blood group system, ISBT symbol H (018), consists of a single antigen (H) defined by a terminal fucose residue found on red blood cells and in secretions formed by the action of α-1,2-fucosyltransferases 1 (α2FucT1) and 2 (α2FucT2), respectively. Mutant alleles of the corresponding FUT1 and FUT2 genes result in either a H– phenotype (Bombay phenotype, Oh) or a weak H phenotype (para-Bombay, H+w). In addition, the FUT2 gene is the molecular basis of the secretor (Se

Erwin Andreas Scharberg, Coral Olsen, Peter Bugert

Immunohematology, Volume 32 , ISSUE 3, 112–118

case-report | 25-June-2021

Neonatal testing leading to the identification of Bh (para-Bombay) phenotype in the mother: case report with review of the literature

The Bombay phenotype was identified in 1952 by Bhende and colleagues.1 The Bombay phenotype results from a homozygous deficiency of the FUT1 gene along with a silenced mutation of the FUT2 gene. The incidence of the Bombay phenotype in the Indian population is approximately 1 in 10,000 and is most often due to a T725G mutation in the FUT1 gene and a 10-kb deletion in the FUT2 gene.2 The para-Bombay phenotype is either due to a point mutation or a silence mutation on the FUT1 gene with a normal

G. Mohan, A. Vaidya, S. Shastry

Immunohematology, Volume 37 , ISSUE 2, 59–63

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